OPN3
| OPN3 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl |
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|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | n/a | Chr 1: 175.49 – 175.52 Mb | |||||||
| PubMed search | [2] | [3] | |||||||
| View/Edit Human | View/Edit Mouse |
Opsin-3 also known as encephalopsin or panopsintranscript variants encoding different protein isoforms.[8]
Function
melanogenesis.[9]
Applications
When OPN3 analogues are expressed in neurons, activation by light inhibits neurotransmitter release.[10][11] This makes these analogues useful tools for optogenetic silencing, a method to study the impact of specific neurons on brain function.
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026525 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 23479626.
- PMID 10234000.
- PMID 11401433.
- ^ a b "Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)".
- ^ PMID 25267311.
- PMID 31653550.
- PMID 33979634.
- PMID 33979635.
Further reading
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Halford S, Bellingham J, Ocaka L, Fox M, Johnson S, Foster RG, Hunt DM (2002). "Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids". Cytogenetics and Cell Genetics. 95 (3–4): 234–235. S2CID 24099335.
- Kasper G, Taudien S, Staub E, Mennerich D, Rieder M, Hinzmann B, et al. (July 2002). "Different structural organization of the encephalopsin gene in man and mouse". Gene. 295 (1): 27–32. PMID 12242008.
- Alam NA, Gorman P, Jaeger EE, Kelsell D, Leigh IM, Ratnavel R, et al. (December 2003). "Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability". Cancer Genetics and Cytogenetics. 147 (2): 121–127. PMID 14623461.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.