TAS2R3
| TAS2R3 | |||
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Gene ontology | |||
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| Location (UCSC) | Chr 7: 141.76 – 141.77 Mb | Chr 6: 40.47 – 40.47 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.[5]
Function
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[5]
Ligands
The only known ligand for TAS2R3 in BitterDB is chloroquine.[6]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127362 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052850 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: TAS2R3 taste receptor, type 2, member 3".
- ^ "hTAS2R3". BitterDB. The Hebrew University of Jerusalem.
Further reading
- Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. S2CID 37807140.
- Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. S2CID 14604586.
- Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. S2CID 7293493.
- Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. S2CID 35741332.
- Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. S2CID 4336913.
- Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. PMID 11437385.
- Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. S2CID 718601.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. PMID 15744053.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.