GPR12
| GPR12 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | Chr 13: 26.76 – 26.76 Mb | Chr 5: 146.52 – 146.52 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[5][6][7]
The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.[8]
Ligands
- Inverse agonists
Evolution
Paralogues
Source:[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 31345248.
- PMID 8530049.
- ^ "Entrez Gene: GPR12 G protein-coupled receptor 12".
- PMID 16887097.
- PMID 28888984.
- ^ "GeneCards®: The Human Gene Database".
Further reading
- Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry. 13 (2): 75–84. S2CID 45156405.