Secretin receptor family
| Secretin family of 7 transmembrane receptors | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | 7tm_2 | ||||||||
TCDB | 9.A.14 | ||||||||
| OPM superfamily | 6 | ||||||||
| OPM protein | 4k5y | ||||||||
| CDD | cd13952 | ||||||||
| |||||||||
Secretin receptor family (class B
The secretin-receptor family of GPCRs include
The secretin-receptor family GPCRs exist in many animal species. Data mining with the Pfam signature has identified members in fungi, although due to their presumed non-hormonal function they are more commonly referred to as Adhesion G protein-coupled receptors, making the Adhesion subfamily the more basal group.[6] Three distinct sub-families (B1-B3) are recognized.
Subfamily B1
Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.
- Pituitary adenylate cyclase-activating polypeptide type 1 receptor InterPro: IPR002285
- Calcitonin receptor InterPro: IPR003287
- Corticotropin-releasing hormone receptor InterPro: IPR003051
- CRHR2
- Glucose-dependent insulinotropic polypeptide receptor/Gastric inhibitory polypeptide receptor InterPro: IPR001749
- GIPR
- Glucagon receptor InterPro: IPR003291
- GCGR
- Glucagon receptor-related InterPro: IPR003290
- GLP2R;
- Growth hormone releasing hormone receptor InterPro: IPR003288
- GHRHR
- Parathyroid hormone receptor InterPro: IPR002170
- PTHR2
- Secretin receptor InterPro: IPR002144
- Vasoactive intestinal peptide receptor InterPro: IPR001571
Subfamily B2
Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin[7] and brain-specific angiogenesis inhibitor receptors[8] amongst others. They are otherwise known as Adhesion G protein-coupled receptors.
- Brain-specific angiogenesis inhibitor InterPro: IPR008077
- CD97 antigen InterPro: IPR003056
- EMR hormone receptor InterPro: IPR001740
- EMR4
- GPR56 orphan receptor InterPro: IPR003910
-
- LPHN3
- Ig-hepta receptor InterPro: IPR008078
Subfamily B3
Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.
Unclassified members
HCTR-5; HCTR-6; KPG 006; KPG 008