GPR158
| GPR158 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 10: 25.17 – 25.6 Mb | Chr 2: 21.37 – 21.84 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),[5] is a protein that in humans is encoded by the GPR158 gene.[6]
Function
This protein is an
It is expressed at lower levels in other organs and shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[8]
Clinical significance
Role in mood regulation
GPR158 in the medial prefrontal cortex (mPFC) has been shown to regulate stress-induced depression in a mouse model of depression and has been found to be upregulated in post-mortem tissue samples from humans with major depressive disorder (MDD).[9]
Role in prostate cancer
The GPR158 gene is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000151025 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045967 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 257836784.
- ^ "Entrez Gene: GPR158 G protein-coupled receptor 158".
- PMID 22689652.
- PMID 23451275.
- PMID 29419376.
- PMID 25693195.
