TAS2R8

TAS2R8
Identifiers
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000277316 ENSG00000121314 ENSG00000272712


n/a

UniProt


Q9NYW2


n/a

RefSeq (mRNA)


NM_023918


n/a

RefSeq (protein)


NP_076407


n/a

Location (UCSC)

Chr 12: 10.81 – 10.81 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.^[3]^[4]^[5]

Function

This gene product belongs to the family of candidate

G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.^[5]

References

^ ^a ^b ^c ENSG00000121314, ENSG00000272712 GRCh38: Ensembl release 89: ENSG00000277316, ENSG00000121314, ENSG00000272712 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
S2CID 14604586
.

S2CID 4336913
.

^ ^a ^b "Entrez Gene: TAS2R8 taste receptor, type 2, member 8".

Further reading

Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10.
PMID 10774719
.

Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4.
PMID 11696554
.

Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71.
S2CID 37807140
.

Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11.
S2CID 7293493
.

Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301.
S2CID 718601
.

Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6.
PMID 15496549
.

Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26.
PMID 15744053
.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v
t
e
Cell surface receptor: G protein-coupled receptors
Class A: Rhodopsin-like
Neurotransmitter
Adrenergic

α1 (A

B

D)

α2 (A

B

C)

β1

β2

β3

Purinergic

Adenosine (A1

A2A

A2B

A3)

P2Y (1

2

4

5

6

8

9

10

11

12

13

14)

Serotonin

(all but 5-HT3) 5-HT1 (A

B

D

E

F)

5-HT2 (A

B

C)

5-HT (4

5A

6

7)

Other

Acetylcholine (M1

M2

M3

M4

M5)

Dopamine
D1

D2

D3

D4

D5

GHB receptor

Histamine
H1

H2

H3

H4

Melatonin (1A

1B

1C)

TAAR (1

2

5

6

8

9)

Metabolites and
signaling molecules
Eicosanoid

CysLT (1

2)

LTB4
1

2

FPRL1

OXE

Prostaglandin
DP (1

1

2

3

4), FP

Prostacyclin

Thromboxane

Other

Bile acid

CB1

18

55

119))

EBI2

Estrogen

Free fatty acid (1

2

3

4)

Hydroxycarboxylic acids
1

2

3

Lysophosphatidic acid (1

2

3

4

5

6)

Lysophospholipid (1

2

3

4

5

6

7

8)

Oxoglutarate

PAF

Sphingosine-1-phosphate (1

2

3

4

5)

Succinate

Peptide
Neuropeptide

B/W (1

2)

FF (1

2)

S

Y (1

2

4

5)

Neuromedin (B

U (1

2))

Neurotensin (1

2)

Other

Anaphylatoxin (C3a

C5a (1

2))

Angiotensin (1

2)

Apelin

Bombesin
BRS3

GRPR

NMBR)

Bradykinin (B1

B2)

Chemokine

Cholecystokinin (A

B)

Endothelin
A

B

Formyl peptide (1

2

3)

FSH

Galanin (1

2

3)

Gonadotropin-releasing hormone (1

2)

Ghrelin

Kisspeptin

Luteinizing hormone/choriogonadotropin

MAS (1

1L

D

E

F

G

X1

X2

X3

X4)

Melanocortin (1

2

3

4

5)

MCHR (1

2)

Motilin

Opioid (Delta

Kappa

Mu

Nociceptin & Zeta, but not Sigma)

Orexin (1

2)

Oxytocin

Prokineticin (1

2)

Prolactin-releasing peptide

Relaxin (1

2

3

4)

Somatostatin (1

2

3

4

5)

Tachykinin (1

2

3)

Thyrotropin

Thyrotropin-releasing hormone

Urotensin-II

1A

1B

2
)

Miscellaneous
Taste, bitter

TAS2R
1

3

4

5

7

8

9

10

13

14

16

19

20

30

31

38

39

40

41

42

43

45

46

50

60

Vomeronasal receptor type 1

Orphan

GPR (1

3

4

6

12

15

17

18

19

20

21

22

23

25

26

27

31

32

33

34

35

37

39

42

44

45

50

52

55

61

62

63

65

68

75

78

81

82

83

84

85

87

88

92

101

103

109A

109B

119

120

132

135

137B

139

141

142

146

148

149

150

151

152

153

160

161

162

171

173

174

176

177

182

183)

Other

Adrenomedullin

Olfactory

Opsin (3

4

5

1LW

1MW

1SW

RGR

RRH)

1

2

3

4)

SREB (1

2

3)

Class B: Secretin-like
Adhesion

ADGRB
Brain-specific angiogenesis inhibitor
1

2

3

ADGRC
Cadherin
1

2

3

ADGRE
EMR
1

2

3

CD97

ADGRG
1

2

3

4

5

6

7

ADGRL
Latrophilin

1

2

3

ELTD1

Orphan

GPR (56

64

97

98

110

111

112

113

114

115

116

123

124

125

126

128

133

143

144

155

157)

Other

Calcitonin

CALCRL

Corticotropin-releasing hormone (1

2)

Glucagon (GR

GIPR

GLP1R

GLP2R)

Growth-hormone-releasing hormone

PACAPR1

GPR

Methuselah-like proteins

Parathyroid hormone (1

2)

Secretin

Vasoactive intestinal peptide (1

2)

Class C: Metabotropic glutamate / pheromone
Taste, sweet

TAS1R
1

2

3

Vomeronasal receptor, type 2

Other

Calcium-sensing receptor

GABA_B (1

2)

Glutamate receptor (Metabotropic glutamate (1

2

3

4

5

6

7

8))

GPRC6A

GPR (156

158

179)

RAIG (1

2

3

4)

Class F: Frizzled & Smoothened
Frizzled

1

2

3

4

5

6

7

8

9

10
)

Smoothened

Smoothened

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[refGRCh38Ensembl-1] ENSG00000121314, ENSG00000272712 GRCh38: Ensembl release 89: ENSG00000277316, ENSG00000121314, ENSG00000272712 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10761934-3] S2CID 14604586
.

[pmid10766242-4] S2CID 4336913
.

[entrez-5] "Entrez Gene: TAS2R8 taste receptor, type 2, member 8".

[2]

[3]

[4]

[5]

Function

See also

References

Further reading