Melanocortin 5 receptor
| MC5R | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 18: 13.82 – 13.83 Mb | Chr 18: 68.47 – 68.48 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Melanocortin 5 receptor (MC5R) is a protein that in humans is encoded by the MC5R gene.[5][6] It is located on the chromosome 18 in the human genome.[6] When the MC5R was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[7]
Physiology
MC5R is necessary for normal
erythrocyte differentiation.[12] MC5R is involved in inflammation.[13][14] MC5R helps maintain thermal homeostasis.[8][15]
MC5R is expressed in the brain at different levels depending on physical activity.[16]
Pheromones
MC5R is heavily expressed in the preputial gland in mice (a modified sebaceous gland involved in pheromone production). MC5R deficiency in male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheromonal signals.[17][18][19]
MRAP
Melanocortin 2 receptor accessory protein (MRAP) traps MC5R protein inside cells.[20]
Evolution
Paralogues[21]
- MC4R
- MC3R
- MC1R
- MC2R
- S1PR1
- LPAR1
- S1PR3
- GPR12
- LPAR2
- GPR3
- S1PR2
- GPR6
- GPR119
- LPAR3
- CNR1
- S1PR5
- S1PR4
- CNR2
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000176136 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007480 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8396929.
- ^ a b "Entrez Gene: MC5R melanocortin 5 receptor".
- ^ PMID 10998132.
- ^ S2CID 6251691.
- PMID 21215742.
- PMID 17127674.
- S2CID 31837693.
- PMID 25860801.
- PMID 24043903.
- PMID 20089716.
- PMID 24981835.
- PMID 22643233.
- S2CID 32531156.
- PMID 14977807.
- S2CID 9659300.
- PMID 19535343.
- ^ "GeneCards®: The Human Gene Database".
Further reading
- Fathi Z, Iben LG, Parker EM (January 1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype". Neurochemical Research. 20 (1): 107–13. S2CID 20792213.
- Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 68 (1–2): 79–81. PMID 7956366.
- Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P (April 1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochemical and Biophysical Research Communications. 200 (2): 1007–14. PMID 8179577.
- Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T (May 1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor" (PDF). Biochemical and Biophysical Research Communications. 200 (3): 1214–20. PMID 8185570.
- Chhajlani V (February 1996). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochemistry and Molecular Biology International. 38 (1): 73–80. PMID 8932521.
- Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I (March 1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Molecular Endocrinology. 11 (3): 274–80. PMID 9058374.
- Frändberg PA, Xu X, Chhajlani V (July 1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochemical and Biophysical Research Communications. 236 (2): 489–92. PMID 9240466.
- Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I (January 1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Molecular Endocrinology. 13 (1): 148–55. PMID 9892020.
- Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL (April 2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor". The Journal of Investigative Dermatology. 116 (4): 564–70. PMID 11286624.
- Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH (October 2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". Journal of Medicinal Chemistry. 44 (22): 3665–72. PMID 11606131.
- Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (January 2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Molecular Pharmacology. 67 (1): 50–9. S2CID 13536417.
- Lohoff FW, Berrettini WH (December 2005). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatric Genetics. 15 (4): 255–8. S2CID 21170090.
- Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ (June 2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5". Peptides. 28 (6): 1191–6. PMID 17482720.
External links
- "Melanocortin Receptors: MC5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-07-14. Retrieved 2008-12-05.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.