GPR149

GPR149
Identifiers
Gene ontology
Molecular function	neuropeptide binding; G protein-coupled receptor activity; signal transducer activity; melanin-concentrating hormone receptor activity; peptide binding;
Cellular component	integral component of membrane; neuron projection; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of ovulation; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; preantral ovarian follicle growth; antral ovarian follicle growth; signal transduction; chemical synaptic transmission;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000174948


ENSMUSG00000043441

UniProt


Q86SP6


Q3UVY1

RefSeq (mRNA)


NM_001038705


NM_177346 NM_001356525

RefSeq (protein)


NP_001033794


NP_796320 NP_001343454

Location (UCSC)

Chr 3: 154.33 – 154.43 Mb

Chr 3: 62.44 – 62.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 149 is a protein that in humans is encoded by the GPR149 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174948 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043441 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 12679517
.

^ "Entrez Gene: GPR149 G protein-coupled receptor 149".

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t
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Cell surface receptor: G protein-coupled receptors
Class A: Rhodopsin-like
Neurotransmitter
Adrenergic

α1 (A

B

D)

α2 (A

B

C)

β1

β2

β3

Purinergic

Adenosine (A1

A2A

A2B

A3)

P2Y (1

2

4

5

6

8

9

10

11

12

13

14)

Serotonin

(all but 5-HT3) 5-HT1 (A

B

D

E

F)

5-HT2 (A

B

C)

5-HT (4

5A

6

7)

Other

Acetylcholine (M1

M2

M3

M4

M5)

Dopamine
D1

D2

D3

D4

D5

GHB receptor

Histamine
H1

H2

H3

H4

Melatonin (1A

1B

1C)

TAAR (1

2

5

6

8

9)

Metabolites and
signaling molecules
Eicosanoid

CysLT (1

2)

LTB4
1

2

FPRL1

OXE

Prostaglandin
DP (1

1

2

3

4), FP

Prostacyclin

Thromboxane

Other

Bile acid

CB1

18

55

119))

EBI2

Estrogen

Free fatty acid (1

2

3

4)

Hydroxycarboxylic acids
1

2

3

Lysophosphatidic acid (1

2

3

4

5

6)

Lysophospholipid (1

2

3

4

5

6

7

8)

Oxoglutarate

PAF

Sphingosine-1-phosphate (1

2

3

4

5)

Succinate

Peptide
Neuropeptide

B/W (1

2)

FF (1

2)

S

Y (1

2

4

5)

Neuromedin (B

U (1

2))

Neurotensin (1

2)

Other

Anaphylatoxin (C3a

C5a (1

2))

Angiotensin (1

2)

Apelin

Bombesin
BRS3

GRPR

NMBR)

Bradykinin (B1

B2)

Chemokine

Cholecystokinin (A

B)

Endothelin
A

B

Formyl peptide (1

2

3)

FSH

Galanin (1

2

3)

Gonadotropin-releasing hormone (1

2)

Ghrelin

Kisspeptin

Luteinizing hormone/choriogonadotropin

MAS (1

1L

D

E

F

G

X1

X2

X3

X4)

Melanocortin (1

2

3

4

5)

MCHR (1

2)

Motilin

Opioid (Delta

Kappa

Mu

Nociceptin & Zeta, but not Sigma)

Orexin (1

2)

Oxytocin

Prokineticin (1

2)

Prolactin-releasing peptide

Relaxin (1

2

3

4)

Somatostatin (1

2

3

4

5)

Tachykinin (1

2

3)

Thyrotropin

Thyrotropin-releasing hormone

Urotensin-II

1A

1B

2
)

Miscellaneous
Taste, bitter

TAS2R
1

3

4

5

7

8

9

10

13

14

16

19

20

30

31

38

39

40

41

42

43

45

46

50

60

Vomeronasal receptor type 1

Orphan

GPR (1

3

4

6

12

15

17

18

19

20

21

22

23

25

26

27

31

32

33

34

35

37

39

42

44

45

50

52

55

61

62

63

65

68

75

78

81

82

83

84

85

87

88

92

101

103

109A

109B

119

120

132

135

137B

139

141

142

146

148

149

150

151

152

153

160

161

162

171

173

174

176

177

182

183)

Other

Adrenomedullin

Olfactory

Opsin (3

4

5

1LW

1MW

1SW

RGR

RRH)

1

2

3

4)

SREB (1

2

3)

Class B: Secretin-like
Adhesion

ADGRB
Brain-specific angiogenesis inhibitor
1

2

3

ADGRC
Cadherin
1

2

3

ADGRE
EMR
1

2

3

CD97

ADGRG
1

2

3

4

5

6

7

ADGRL
Latrophilin

1

2

3

ELTD1

Orphan

GPR (56

64

97

98

110

111

112

113

114

115

116

123

124

125

126

128

133

143

144

155

157)

Other

Calcitonin

CALCRL

Corticotropin-releasing hormone (1

2)

Glucagon (GR

GIPR

GLP1R

GLP2R)

Growth-hormone-releasing hormone

PACAPR1

GPR

Methuselah-like proteins

Parathyroid hormone (1

2)

Secretin

Vasoactive intestinal peptide (1

2)

Class C: Metabotropic glutamate / pheromone
Taste, sweet

TAS1R
1

2

3

Vomeronasal receptor, type 2

Other

Calcium-sensing receptor

GABA_B (1

2)

Glutamate receptor (Metabotropic glutamate (1

2

3

4

5

6

7

8))

GPRC6A

GPR (156

158

179)

RAIG (1

2

3

4)

Class F: Frizzled & Smoothened
Frizzled

1

2

3

4

5

6

7

8

9

10
)

Smoothened

Smoothened

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174948 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043441 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12679517-5] PMID 12679517
.

[entrez-6] "Entrez Gene: GPR149 G protein-coupled receptor 149".

[3]

[4]

[5]

[6]