GPR75
| GPR75 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 2: 53.85 – 53.86 Mb | Chr 11: 30.84 – 30.84 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Probable G-protein coupled receptor 75 is a protein that in humans is encoded by the GPR75 gene.[5][6]
Function
GPR75 is a member of the
guanine-nucleotide binding proteins upon the binding of a ligand.[6]
GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study, the chemokine
inositol triphosphate formation in GPR75-transfected cells.[7]
A 2021 study reported that people with protein-truncating variants of GPR75 were associated with 5.3kg lower body weight and 54% lower odds for obesity. GPR75 knock-out mice showed resistance to weight gain under high-fat diet.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000119737 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043999 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10381362.
- ^ a b "Entrez Gene: GPR75 G protein-coupled receptor 75".
- PMID 17001303.
- S2CID 235699731.