Neuropeptide Y receptor Y2
Neuropeptide Y receptor type 2 (Y2R) is a member of the
Selective ligands
Agonists
- Neuropeptide Y (endogenous agonist, non subtype selective)
- Neuropeptide Y fragment 13-36 (NPY2 selective agonist)
- Peptide YY
- Peptide YY 3-36 fragment[7]
Antagonists
- BIIE-0246 (CAS# 246146-55-4)
- JNJ 5207787 (CAS# 683746-68-1)
- SF 11 (CAS# 443292-81-7)
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185149 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028004 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7559383.
- ^ "Entrez Gene: NPY2R neuropeptide Y receptor Y2".
- S2CID 24899878.
External links
- "Neuropeptide Y Receptors: Y2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
Further reading
- Wan CP, Lau BH (Feb 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. PMID 9001438.
- Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. PMID 12007534.
- Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (Jul 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. PMID 1321422.
- Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL (Nov 1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". The Journal of Biological Chemistry. 270 (45): 26758–61. PMID 7592910.
- Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K (Mar 1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". The Journal of Biological Chemistry. 269 (11): 8226–33. PMID 8132547.
- Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA (Feb 1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor". Molecular Pharmacology. 49 (2): 224–8. PMID 8632753.
- Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–5. PMID 8643460.
- Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA (Dec 1996). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics. 38 (3): 392–8. PMID 8975716.
- Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (Jul 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry. 273 (28): 17749–55. PMID 9651375.
- Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL (Sep 1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience. 86 (1): 167–78. S2CID 45849983.
- Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M (Jul 2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Molecular Pharmacology. 60 (1): 124–34. S2CID 11573265.
- Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. PMID 11906964.
- Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. S2CID 31244551.
- Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM (Jun 2003). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". British Journal of Pharmacology. 139 (4): 863–71. PMID 12813010.
- Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS (Sep 2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes. 53 (9): 2461–6. PMID 15331560.
- Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B (Feb 2021). "Structural basis for ligand recognition of the neuropeptide Y Y2 receptor". Nature Communications. 12 (1): 737. PMID 33531491.