Melanin-concentrating hormone receptor 1
| MCHR1 | |||
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| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 22: 40.68 – 40.68 Mb | Chr 15: 81.12 – 81.12 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Melanin-concentrating hormone receptor 1, also known as MCH1, is one of the melanin-concentrating hormone receptors found in all mammals.[5]
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds
melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.[5]
Function
MCH1 is thought to have a number of functions including in the regulation of appetite,[6][7] and in stress, anxiety and depression.[8][9][10][11][12][13]
Selective ligands
Agonists
- Melanin concentrating hormone(MCH)
- S-36057 - modified MCH 6-13 fragment substituted with 3-iodotyrosine at N-terminus via dioxyoctanoyl linker, used as 125I radioligand for mapping MCH1 in vivo.[14][15]
- LK-184 (Procter & Gamble) is one pick[16]
Antagonists
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000128285 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050164 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1".
- PMID 17655875.
- PMID 18393860.
- S2CID 25629841.
- S2CID 32524553.
- S2CID 37420990.
- PMID 16205780.
- S2CID 39334337.
- PMID 18227983.
- PMID 11375253.
- PMID 19540226.
- PMID 15225714.
- PMID 16614734.
- S2CID 7770969.
- S2CID 13219655.
- S2CID 717425.
- PMID 11909603.
Further reading
- Kolakowski LF, Jung BP, Nguyen T, Johnson MP, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF (Dec 1996). "Characterization of a human gene related to genes encoding somatostatin receptors". FEBS Letters. 398 (2–3): 253–8. PMID 8977118.
- Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS, Park J, Ellis C, Ganguly S, Konchar S, Cluderay J, Leslie R, Wilson S, Sarau HM (Jul 1999). "Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1". Nature. 400 (6741): 261–5. S2CID 4361829.
- Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli O (Jul 1999). "Molecular characterization of the melanin-concentrating-hormone receptor". Nature. 400 (6741): 265–9. S2CID 4408039.
- Shimomura Y, Mori M, Sugo T, Ishibashi Y, Abe M, Kurokawa T, Onda H, Nishimura O, Sumino Y, Fujino M (Aug 1999). "Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor". Biochemical and Biophysical Research Communications. 261 (3): 622–6. PMID 10441476.
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. PMID 10591208.
- Macdonald D, Murgolo N, Zhang R, Durkin JP, Yao X, Strader CD, Graziano MP (Jul 2000). "Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation". Molecular Pharmacology. 58 (1): 217–25. S2CID 10757485.
- An S, Cutler G, Zhao JJ, Huang SG, Tian H, Li W, Liang L, Rich M, Bakleh A, Du J, Chen JL, Dai K (Jun 2001). "Identification and characterization of a melanin-concentrating hormone receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7576–81. PMID 11416225.
- Bednarek MA, Feighner SD, Hreniuk DL, Palyha OC, Morin NR, Sadowski SJ, MacNeil DJ, Howard AD, Van der Ploeg LH (Aug 2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2". Biochemistry. 40 (31): 9379–86. PMID 11478907.
- Bednarek MA, Tan C, Hreniuk DL, Palyha OC, MacNeil DJ, Van Der Ploeg LH, Howard AD, Feighner SD (Apr 2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1". The Journal of Biological Chemistry. 277 (16): 13821–6. PMID 11839762.
- Audinot V, Lahaye C, Suply T, Rovère-Jovène C, Rodriguez M, Nicolas JP, Beauverger P, Cardinaud B, Galizzi JP, Fauchère JL, Nahon JL, Boutin JA (Jul 2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor". Biochemical and Biophysical Research Communications. 295 (4): 841–8. PMID 12127971.
- Hoogduijn MJ, Ancans J, Suzuki I, Estdale S, Thody AJ (Aug 2002). "Melanin-concentrating hormone and its receptor are expressed and functional in human skin". Biochemical and Biophysical Research Communications. 296 (3): 698–701. PMID 12176038.
- Bächner D, Kreienkamp HJ, Richter D (Aug 2002). "MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein". FEBS Letters. 526 (1–3): 124–8. PMID 12208518.
- Verlaet M, Adamantidis A, Coumans B, Chanas G, Zorzi W, Heinen E, Grisar T, Lakaye B (Sep 2002). "Human immune cells express ppMCH mRNA and functional MCHR1 receptor" (PDF). FEBS Letters. 527 (1–3): 205–10. PMID 12220661.
- Logan DW, Bryson-Richardson RJ, Pagán KE, Taylor MS, Currie PD, Jackson IJ (Feb 2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals". Genomics. 81 (2): 184–91. PMID 12620396.
- Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E (Aug 2003). "Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways". Endocrinology. 144 (8): 3514–23. PMID 12865333.
- Gottumukkala RV, Waterman EA, Herd LM, Gawkrodger DJ, Watson PF, Weetman AP, Kemp EH (Oct 2003). "Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor". The Journal of Investigative Dermatology. 121 (4): 765–70. PMID 14632194.
- Gibson WT, Pissios P, Trombly DJ, Luan J, Keogh J, Wareham NJ, Maratos-Flier E, O'Rahilly S, Farooqi IS (May 2004). "Melanin-concentrating hormone receptor mutations and human obesity: functional analysis". Obesity Research. 12 (5): 743–9. PMID 15166293.
- Hawes BE, Green B, O'Neill K, Fried S, Arreaza MG, Qiu P, Simon JS (Aug 2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2". Obesity Research. 12 (8): 1327–34. PMID 15340116.
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. PMID 15461802.
External links
- "Melanin-Concentrating Hormone Receptors: MCH1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.