TAS2R39

TAS2R39
Available structures
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
	ENSG00000236398
	ENSMUSG00000047102
	P59534
	Q7TQA5
	NM_176881
	NM_181275
	NP_795362
	NP_851792
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000236398 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047102 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
S2CID 20426192
.

^ "Entrez Gene: TAS2R39 taste receptor, type 2, member 39".

Further reading

Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4.
PMID 11696554
.

Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71.
S2CID 37807140
.

Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301.
S2CID 718601
.

Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6.
PMID 15496549
.

Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26.
PMID 15744053
.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v
t
e
Cell surface receptor: G protein-coupled receptors
Class A: Rhodopsin-like
Neurotransmitter
Adrenergic

α1 (A

B

D)

α2 (A

B

C)

β1

β2

β3

Purinergic

Adenosine (A1

A2A

A2B

A3)

P2Y (1

2

4

5

6

8

9

10

11

12

13

14)

Serotonin

(all but 5-HT3) 5-HT1 (A

B

D

E

F)

5-HT2 (A

B

C)

5-HT (4

5A

6

7)

Other

Acetylcholine (M1

M2

M3

M4

M5)

Dopamine
D1

D2

D3

D4

D5

GHB receptor

Histamine
H1

H2

H3

H4

Melatonin (1A

1B

1C)

TAAR (1

2

5

6

8

9)

Metabolites and
signaling molecules
Eicosanoid

CysLT (1

2)

LTB4
1

2

FPRL1

OXE

Prostaglandin
DP (1

1

2

3

4), FP

Prostacyclin

Thromboxane

Other

Bile acid

CB1

18

55

119))

EBI2

Estrogen

Free fatty acid (1

2

3

4)

Hydroxycarboxylic acids
1

2

3

Lysophosphatidic acid (1

2

3

4

5

6)

Lysophospholipid (1

2

3

4

5

6

7

8)

Oxoglutarate

PAF

Sphingosine-1-phosphate (1

2

3

4

5)

Succinate

Peptide
Neuropeptide

B/W (1

2)

FF (1

2)

S

Y (1

2

4

5)

Neuromedin (B

U (1

2))

Neurotensin (1

2)

Other

Anaphylatoxin (C3a

C5a (1

2))

Angiotensin (1

2)

Apelin

Bombesin
BRS3

GRPR

NMBR)

Bradykinin (B1

B2)

Chemokine

Cholecystokinin (A

B)

Endothelin
A

B

Formyl peptide (1

2

3)

FSH

Galanin (1

2

3)

Gonadotropin-releasing hormone (1

2)

Ghrelin

Kisspeptin

Luteinizing hormone/choriogonadotropin

MAS (1

1L

D

E

F

G

X1

X2

X3

X4)

Melanocortin (1

2

3

4

5)

MCHR (1

2)

Motilin

Opioid (Delta

Kappa

Mu

Nociceptin & Zeta, but not Sigma)

Orexin (1

2)

Oxytocin

Prokineticin (1

2)

Prolactin-releasing peptide

Relaxin (1

2

3

4)

Somatostatin (1

2

3

4

5)

Tachykinin (1

2

3)

Thyrotropin

Thyrotropin-releasing hormone

Urotensin-II

1A

1B

2
)

Miscellaneous
Taste, bitter

TAS2R
1

3

4

5

7

8

9

10

13

14

16

19

20

30

31

38

39

40

41

42

43

45

46

50

60

Vomeronasal receptor type 1

Orphan

GPR (1

3

4

6

12

15

17

18

19

20

21

22

23

25

26

27

31

32

33

34

35

37

39

42

44

45

50

52

55

61

62

63

65

68

75

78

81

82

83

84

85

87

88

92

101

103

109A

109B

119

120

132

135

137B

139

141

142

146

148

149

150

151

152

153

160

161

162

171

173

174

176

177

182

183)

Other

Adrenomedullin

Olfactory

Opsin (3

4

5

1LW

1MW

1SW

RGR

RRH)

1

2

3

4)

SREB (1

2

3)

Class B: Secretin-like
Adhesion

ADGRB
Brain-specific angiogenesis inhibitor
1

2

3

ADGRC
Cadherin
1

2

3

ADGRE
EMR
1

2

3

CD97

ADGRG
1

2

3

4

5

6

7

ADGRL
Latrophilin

1

2

3

ELTD1

Orphan

GPR (56

64

97

98

110

111

112

113

114

115

116

123

124

125

126

128

133

143

144

155

157)

Other

Calcitonin

CALCRL

Corticotropin-releasing hormone (1

2)

Glucagon (GR

GIPR

GLP1R

GLP2R)

Growth-hormone-releasing hormone

PACAPR1

GPR

Methuselah-like proteins

Parathyroid hormone (1

2)

Secretin

Vasoactive intestinal peptide (1

2)

Class C: Metabotropic glutamate / pheromone
Taste, sweet

TAS1R
1

2

3

Vomeronasal receptor, type 2

Other

Calcium-sensing receptor

GABA_B (1

2)

Glutamate receptor (Metabotropic glutamate (1

2

3

4

5

6

7

8))

GPRC6A

GPR (156

158

179)

RAIG (1

2

3

4)

Class F: Frizzled & Smoothened
Frizzled

1

2

3

4

5

6

7

8

9

10
)

Smoothened

Smoothened

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v
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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000236398 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047102 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12379855-5] S2CID 20426192
.

[entrez-6] "Entrez Gene: TAS2R39 taste receptor, type 2, member 39".

[3]

[4]

[5]

[6]

See also

References

Further reading