Neuropeptide Y receptor Y1
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| Location (UCSC) | Chr 4: 163.32 – 163.34 Mb | Chr 8: 67.15 – 67.16 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[5][6]
Selective ligands
Agonists
- Neuropeptide Y (endogenous agonist, non subtype selective)
- Peptide YY
Antagonists
- Peptide
- BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
- GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
- Non-peptide
- BIBO-3304 (CAS# 191868-14-1)
- BIBP-3226 (CAS# 159013-54-4)
- PD-160,170 (CAS# 181468-88-2)
Available Structures
- 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)[7]
- 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164128 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036437 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8095935.
- ^ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
- ^ PMID 29670288.
Further reading
- Wan CP, Lau BH (February 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. PMID 9001438.
- Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. PMID 12007534.
- Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers. 60 (6): 420–37. PMID 12209475.
- Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C (June 1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". The Journal of Biological Chemistry. 267 (16): 10935–8. PMID 1317848.
- Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (July 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. PMID 1321422.
- Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (September 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. PMID 7559383.
- Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL (February 2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". The Journal of Biological Chemistry. 277 (8): 6645–55. PMID 11741903.
- Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A (January 2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides. 23 (1): 87–96. S2CID 54419749.
- Cox HM, Tough IR (March 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. PMID 11906964.
- Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. S2CID 31244551.
- Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM (September 2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia. 39 (3): 320–4. S2CID 41750584.
- Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (July 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics. 306 (1): 147–56. S2CID 40163065.
- Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. PMID 15231747.
- Körner M, Waser B, Reubi JC (December 2004). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clinical Cancer Research. 10 (24): 8426–33. PMID 15623622.
External links
- "Neuropeptide Y Receptors: Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
- Overview of all the structural information available in the PDB for UniProt: P25929 (Neuropeptide Y receptor type 1) at the PDBe-KB.