GPR35

G protein-coupled receptor 35 also known as GPR35 is a

Ligands

Endogenous ligands

Although GPR35 is still considered an orphan receptor, there have been attempts to deorphanize it by identifying

• kynurenic acid^[7][8]
• LPA species^[7]
• cyclic guanosine monophosphate^[9]
• DHICA^[10]
• T₃^[10]
• reverse T₃^[10]

Synthetic agonists

Other synthetic

• cromoglicic acid^[11]
• nedocromil^[11]
• pamoic acid^[7]
• zaprinast^[7][12]
• lodoxamide^[13]
• bufrolin^[13]

Antagonists of GPR35 include:

• ML145 (CID-2286812)^[16]
• ML144 (CID-1542103)^[16]

Both ML145 and ML144 unfurl their antagonistic activity through inverse agonism. They are, however, highly species-selective, and practically inactive at the rodent receptor orthologues.^[17]

Clinical significance

Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome and is mutated in 2q37 monosomy and 2q37 deletion syndrome.^[18] In one study GPR35 has been recognised as a potential oncogene in stomach cancer.^[19]

References