Neuropeptide Y receptor Y5
Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.[5][6][7]
Selective ligands
Agonists
- Neuropeptide Y (endogenous agonist, non subtype selective)
- BWX-46 (selective NPY5 agonist, CAS# 172997-92-1)
- Peptide YY
Antagonists
- CGP-71683 (CAS# 192322-50-2)
- FMS-586[8]
- L-152,804 (CAS# 6508-43-6)
- Lu AA-33810[9]
- MK-0557[10]
- NTNCB (CAS# 486453-65-0)[11]
- Velneperit (S-2367)
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164129 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044014 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 4286144.
- PMID 9417917.
- ^ "Entrez Gene: NPY5R neuropeptide Y receptor Y5".
- S2CID 6064389.
- S2CID 20295744.
- PMID 17979781. Archived from the originalon 2013-01-12. Retrieved 2020-04-16.
- PMID 12067557.
Further reading
- Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. PMID 12007534.
- Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N, McCaleb ML (Oct 1996). "Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior". The Journal of Biological Chemistry. 271 (42): 26315–9. PMID 8824284.
- Herzog H, Darby K, Ball H, Hort Y, Beck-Sickinger A, Shine J (May 1997). "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation". Genomics. 41 (3): 315–9. PMID 9169127.
- Nichol KA, Morey A, Couzens MH, Shine J, Herzog H, Cunningham AM (Dec 1999). "Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control". The Journal of Neuroscience. 19 (23): 10295–304. PMID 10575027.
- Rodriguez M, Audinot V, Dromaint S, Macia C, Lamamy V, Beauverger P, Rique H, Imbert J, Nicolas JP, Boutin JA, Galizzi JP (Feb 2003). "Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform". The Biochemical Journal. 369 (Pt 3): 667–73. PMID 12398768.
- Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (Jul 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics. 306 (1): 147–56. S2CID 40163065.
- Beauverger P, Rodriguez M, Nicolas JP, Audinot V, Lamamy V, Dromaint S, Nagel N, Macia C, Léopold O, Galizzi JP, Caignard DH, Aldana I, Monge A, Chomarat P, Boutin JA (Apr 2005). "Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay". Cellular Signalling. 17 (4): 489–96. PMID 15601626.
- Movafagh S, Hobson JP, Spiegel S, Kleinman HK, Zukowska Z (Sep 2006). "Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors". FASEB Journal. 20 (11): 1924–6. S2CID 5566843.
- Coletta DK, Schneider J, Stern MP, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP (Apr 2007). "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans". Obesity. 15 (4): 809–15. S2CID 21069742.
External links
- "Neuropeptide Y Receptors: Y5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.