TAAR2
| TAAR2 | |||
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| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 6: 132.62 – 132.62 Mb | Chr 10: 23.81 – 23.82 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Trace amine-associated receptor 2 (TAAR2), formerly known as G protein-coupled receptor 58 (GPR58), is a protein that in humans is encoded by the TAAR2 gene.[5][6][7][8] TAAR2 is coexpressed with Gα proteins;[8] however, as of February 2017,[update] its signal transduction mechanisms have not been determined.[8]
Tissue distribution
Human TAAR2 (hTAAR2) is expressed in the
Using brain histochemistry staining of mice with LacZ insertion into TAAR2 gene histochemical reaction was found in the glomerular layer of the
Involvement in the functioning of monoamine systems
TAAR2
Involvement in adult neurogenesis
It has been found that TAAR2 knockout mice have an increased number of neuroblast-like and proliferating cells in both subventricular and subgranular zones of the dentate gyrus in comparison to wild type animals. Furthermore, TAAR2 knockout mice have an increased the brain-derived neurotrophic factor (BDNF) level in the striatum.[12]
A
Involvement in immune cell migration and function
TCells, B Cells and Peripheral Mononuclear cells express TAAR2 mRNA. Migration toward TAAR1 ligands required both TAAR1 and TAAR2 expression based on siRNA experiments.[11] In T cells, the same stimuli triggered cytokine secretion while in B cells Immunoglobulin secretion is triggered.[11]
Possible Ligands
3‐iodo‐thyronamine(T1AM) was identified as a nonselective ligand for TAAR2.[10] Additional TAAR1 ligands, p-tyramine and Beta-phenylethylamine(2-PEA) trigger TAAR2 dependant actions, though direct binding has not been demonstrated.[11]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000146378 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059763 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10684976.
- PMID 15718104.
- ^ "Entrez Gene: TAAR2 trace amine associated receptor 2".
- ^ a b c d e Davenport AP, Alexander S, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga C, Battey J, Benya RV, Jensen RT, Karnik S, Kostenis E, Spindel E, Storjohann L, Tirupula K, Bonner TI, Neubig R, Pin JP, Spedding M, Harmar A (25 June 2015). "TAAR2". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. Retrieved 22 February 2017.
- ^ PMID 27424325.
- ^ S2CID 21073152.
- ^ S2CID 206996784.
- ^ PMID 35431833.
- S2CID 226986365.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.