RRH
| RRH | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 4: 109.83 – 109.85 Mb | Chr 3: 129.6 – 129.62 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Peropsin, a visual pigment-like receptor, is a
Photochemistry
Like most opsins, peropsins have in its seventh transmembrane domain a lysine corresponding to amino acid position 296 in cattle rhodopsin,[5][7] which is important for retinal binding and light sensing.[8]
In
Tissue localization
In mice, a peropsin is localized to the apical
Gene localization and structure
The human peropsin gene lies on chromosome 4 band 4q25 and has six introns[6][18] like RGR-opsins. However only two of these introns are inserted at the same place, which still indicates that peropsins and RGR-opsins are more closely related to each other than to the ciliary and rhabdomeric opsins.[18] This shared gene structure is also reflected in opsin phylogenies, where peropsins and RGR-opsins are in the same group: The chromopsins.[18][7][19][20]
Phylogeny
The peropsins are restricted to the
-
Phylogenetic reconstruction of the opsins. The outgroup contains other G protein-coupled receptors. The frame highlights the tetraopsins, which are expanded in the next image. -
Phylogenetic reconstruction of the tetraopsins. The outgroup contains other G protein-coupled receptors including the other opsins. The frame highlights the chromopsins, which are expanded in the next image. -
Phylogenetic reconstruction of the chromopsins. The outgroup contains other G protein-coupled receptors including the other opsins. The frame highlights the peropsins.
In the
Clinical significance
Since RGR-opsin may be associated with retinitis pigmentosa,[22] which is like peropsin also expressed in the retinal pigment epithelium, peropsin was screened for a link with retinitis pigmentosa.[23] However, no link could be established.[23][24]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000180245 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028012 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 9275222.
- ^ a b c "Entrez Gene: RRH retinal pigment epithelium-derived rhodopsin homolog".
- ^ PMID 35954284..
Material was copied and adapted from this source, which is available under a Creative Commons Attribution 4.0 International License - PMID 32243853.
- ^ S2CID 11669142.
- S2CID 4022911.
- PMID 16589696.
- PMID 13367054.
- .
- PMID 16589909.
- PMID 29109151.
- S2CID 1373924.
- PMID 14985289.
- ^ PMID 12542842.
- ^ PMID 27797948.
- ^ PMID 22012981.
- PMID 26154478.
- S2CID 35176366.
- ^ S2CID 225451.
- PMID 17167409.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.