List of investigational analgesics
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This is a list of investigational analgesics, or analgesics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Opioid receptor modulators
- Desmetramadol (O-desmethyltramadol; Omnitram) – μ-opioid receptor agonist, norepinephrine reuptake inhibitor (NRI), and 5-HT2C receptor antagonist.[3]
- Lexanopadol (GRT-6006, GRT13106G) – non-selective opioid receptor agonist[4]
- Oxycodone/naltrexone – combination of a μ-opioid receptor agonist and a μ- and κ-opioid receptor antagonist.[5]
Sodium channel blockers
- BIIB-095 – state-dependent and use-dependent Nav blocker, including Nav1.7.[6]
- CC-8464 (ASP-1807) – selective Nav1.7 blocker[7]
- Cenobamate (YKP-3089) – atypical voltage-gated sodium channel blocker.[8][9]: 5593–5605 [10]
- DSP-2230 – selective Nav1.7 and Nav1.8 blocker.[11]
- Funapide (TV-45070, XEN402) – selective Nav1.7 and Nav1.8 blocker.[12]
- GDC-0276 (RG-7893) – selective Nav1.7 blocker [1]
- GDC-0310 (RG-6029) – selective Nav1.7 blocker [2]
- NKTR-171 – voltage-gated sodium channel blocker [3]
- PF-05089771 – selective Nav1.7 and Nav1.8 blocker [4]
- Ralfinamide (NW-1029) – non-selective voltage-gated sodium channel blocker, as well as other actions [5]
- Tetrodotoxin (9401-TTX; Tectin, Tetrodin, Tocudin) – non-selective voltage-gated sodium channel blocker [6]
- Vixotrigine (formerly raxatrigine; CNV1014802, GSK-1014802, BIIB 074) – non-selective voltage-gated sodium channel blocker [7][citation needed]
- VX-150 – selective Nav1.8 blocker [8]
Calcium channel blockers
- HSK16149 – selective ligand of α2δ subunit of voltage-gated calcium channel [9]
TRP channel modulators
- Capsaicin (Adlea, ALGRX-4975, CNTX-4975, VLNX-4975) – TRPV1 agonist [10]
- COX-2 inhibitor for topical application [11]
- CB2 receptor modulator [12]
- DWP-05195 (TR-1) – TRPV1 antagonist [13]
- GRC-6211 – TRPV1 agonist [14]
- JNJ-38893777 – TRPV1 antagonist [15]
- Mavatrep (JNJ‐39439335) – TRPV1 antagonist.[15]: 712–726 [16]
- NEO-6860 – TRPV1 antagonist [16]
- Parentide (DD-04107) – TRPV1 antagonist [17]
- Resiniferatoxin (RTX; MCP-101) – TRPV1 agonist [18]
- SAR-115740 – TRPV1 antagonist [19]
- Tivanisiran (SYL-1001) – TRPV1 antagonist [20]
Cannabinoid receptor modulators
- ABX-1431 – selective monoacylglycerol lipase inhibitor[21]
- Cannabidiol (CBD) – cannabinoid receptor modulator [22][23]
- Cannabidivarin (CBDV; GWP-42006) – cannabinoid receptor modulator [24]
- CMX-020 – TRPV1 modulator as well as CB1 and CB2 receptor modulator [25]
- Dronabinol (Δ9-THC; ECP022A, Namisol) – CB1 and CB2 receptor agonist [26][27]
- Nabilone – CB1 and CB2 receptor agonist [28]
- NEO-1940 – CB1 and CB2 receptor agonist [29]
- Olorinab (APD-371) – CB2 receptor agonist [30]
Nerve growth factor inhibitors
- Fasinumab (REGN-475, SAR-164877) – monoclonal antibody against nerve growth factor[31]
- Fulranumab (AMG-403, JNJ-42160443) – monoclonal antibody against nerve growth factor [32]
- TrkA[33]
- kinase inhibitor[34]
- decoy receptor for nerve growth factor [35]
- NRD135S-E1 – tyrosine kinase modulator[36][37]
- kinase inhibitor[38]
- Ranevetmab (NV-01) – monoclonal antibody against nerve growth factor for dogs [39]
- Tanezumab (PF-4383119, RI-624, RN-624) – monoclonal antibody against nerve growth factor [40]
- VM-902A – selective, peripherally selective allosteric inhibitor of TrkA [41]
Others
- ALLOD-2 – undefined mechanism of action [42]
- imidazoline I2 receptor agonist [43]
- E-52862 (MR-309; S1A; S1RA) – sigma-1 receptor antagonist [44]
- HSP-3150 – undefined mechanism of action [45]
- nicotinic acetylcholine receptor antagonist [46]
- LATER – CRISPR-dCas9 gene-editing[17]
- PAX-01 – undefined mechanism of action [47]
See also
- List of investigational drugs
References
- ^ "Drug profile | Axelopran/oxycodone". AdisInsight. Theravance Biopharma. 1 October 2021. Retrieved 29 October 2022.
- ^ "Drug profile | Cebranopadol". AdisInsight. Tris Pharma. 14 August 2022. Retrieved 29 October 2022.
- ^ "Drug profile | Desmetramadol". AdisInsight. Syntrix Biosystems. 5 October 2021. Retrieved 2 November 2022.
- ^ "Drug profile | Lexanopadol". AdisInsight. 20 August 2018. Archived from the original on 25 December 2018. Retrieved 2 November 2022.
- ^ "Drug profile | Oxycodone/naltrexone". AdisInsight. Elite Pharmaceuticals. 16 April 2021. Archived from the original on 14 November 2022. Retrieved 14 November 2022.
- ^ "Drug profile | BIIB 095". AdisInsight. Biogen. 7 May 2021. Archived from the original on 14 November 2022. Retrieved 14 November 2022.
- ^ Drug profile | CC 8464. Chromocell Corporation. 28 November 2019. Archived from the original on 15 March 2022. Retrieved 14 November 2022.
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ignored (help) - ^ "Drug profile | Cenobamate". AdisInsight. SK biopharmaceuticals. 28 November 2019. Archived from the original on 14 November 2022. Retrieved 14 November 2022.
- S2CID 3676340.
- S2CID 80887455.
- Sumitomo Dainippon Pharma. 4 April 2022. Archivedfrom the original on 14 November 2022. Retrieved 14 November 2022.
- ^ Drug profile | Funapide. Xenon Pharmaceuticals. 6 September 2022. Archived from the original on 14 November 2022. Retrieved 14 November 2022.
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:|work=
ignored (help) - ^ Nichols, Heather (19 July 2021). "Vertex Initiates Phase 2 Clinical Trial Program for VX-548 for the Treatment of Acute Pain". Vertex Pharmaceuticals (Press Release). Retrieved 14 November 2022.
Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that it has begun a Phase 2 proof-of-concept (POC) study in acute pain following bunionectomy surgery with the selective NaV1.8 inhibitor VX-548 and that it expects to commence a second Phase 2 study in acute pain following abdominoplasty surgery in the coming weeks.
- from the original on 19 May 2022. Retrieved 14 November 2022.
"There is an enormous need for novel non-opioid analgesics with no abuse liability," and Vertex's results are an "important advance," said Dr. Clifford J. Woolf, director of the F.M. Kirby Neurobiology Center and Boston Children's Hospital. It will be important for Vertex to determine whether the drug also works for patients with chronic pain, such as diabetic neuropathy and low back pain, "where the clinical need is highest," he added.
- S2CID 11755963.
- S2CID 32666782.
- PMID 33692134.