Phenadoxone

Source: Wikipedia, the free encyclopedia.
Phenadoxone
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • 6-Morpholin-4-yl-4,4-diphenylheptan-3-one
JSmol)
Melting point75.5 °C (167.9 °F)
  • O=C(C(c1ccccc1)(c2ccccc2)CC(N3CCOCC3)C)CC
  • InChI=1S/C23H29NO2/c1-3-22(25)23(20-10-6-4-7-11-20,21-12-8-5-9-13-21)18-19(2)24-14-16-26-17-15-24/h4-13,19H,3,14-18H2,1-2H3 checkY
  • Key:LOXCOAXRHYDLOW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Phenadoxone (trade names Heptalgin, Morphidone, and Heptazone) is an

alphaprodine
(Nisentil).

Phenadoxone has a US DEA ACSCN of 9637 and recently has had a zero annual manufacturing quota under the Controlled Substances Act 1970.[6] Its withdrawal from US distribution prior to the promulgation of said act is a large part of its Schedule I designation; it is, however, used as a legitimate medication in other countries and consumption is increasing worldwide as indicated below.

Phenadoxone is generally considered to be a strong opioid analgesic and is regulated in much the same way as morphine where it is used. The usual starting dose is 10–20 mg and it has a duration of analgesic effect of 1 to 4 hours. Phenadoxone is not used at this time for purposes other than pain relief.

Worldwide consumption of phenadoxone has actually increased slightly in recent years according to a recent report from the World Health Organization. Like its drug subcategory prototype methadone, phenadoxone can be used as the opioid analgesic in Brompton cocktail. Phenadoxone is most used at the current time in Denmark and various countries in eastern Europe.

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ "Phenadoxone". Merck Index. 2000.
  3. ^ Physicians' Desk Reference. 1965.
  4. ^ US 2513173, Benjamin AR, Elks J, "4,4-diphenyl-6-morpholino-heptanone-3 and acid salts thereof", assigned to Glaxo 
  5. PMID 15405474
    .
  6. ^ "Quotas - 2013". Diversion Control Division. US Department of Justice, Drug Enforcement Administration.
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