Paracetamol/metoclopramide

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"Paramax" redirects here. For other uses, see Paramax (disambiguation).
Paracetamol/metoclopramide
Combination of
ParacetamolAnalgesic
MetoclopramideDopamine antagonist
Clinical data
Routes of
administration		Oral
Legal status
Legal status
  • AU: S3 (Pharmacist only)
  • UK: POM (Prescription only)
  • OTC (CH
    )
Identifiers
CAS Number
  (verify)

Paracetamol/metoclopramide hydrochloride is an oral

Sanofi-Synthelabo,[1] and in Switzerland as Migraeflux MCP,[2]
in Australia it is sold as Meteclomax and Anagraine.

The combination is used to treat the symptoms of

absorption of paracetamol.[1] However the improvement in paracetamol absorption has been questioned.[3]

The combination of metoclopramide to the paracetamol has been shown to enhance the analgesia relief when used to treat the pain of arthritis.[4]

Whilst the individual component drugs may be prescribed individually, as a combination, it is only available as the branded Paramax preparation in the UK.[5] In the UK there are only two other combination analgesics with antiemetics (i.e., anti-nausea) products available: MigraMax (aspirin with metoclopramide) and the over-the-counter drug Migraleve (paracetamol and codeine for analgesia, with buclizine as the antiemetic).[6] The role for these products is between just the use of simple analgesics (paracetamol or ibuprofen) and the triptan class of drugs; although the latter are not options during pregnancy.[7] In the elderly although triptans are generally avoided, so too are antiemetics such as metoclopramide due to higher risks of side effects. In Australia and New Zealand, the combination is available without prescription from pharmacies.[8]

References

  1. ^ a b Electronic Medicines Compendium: Paramax Tablets, Paramax Sachets (accessed 22 April 2008)
  2. ^ [1]
  3. PMID 6639847
    .
  4. PMID 6653133
    .
  5. ^ "Paramax (paracetamol, metoclopramide)". NetDoctor.co.uk. June 2, 2017 [2008]. Retrieved 2008-04-22.
  6. ^ "4.7.4.1 Treatment of acute migraine". British National Formulary (55th ed.). March 2008. p. 239.
  7. S2CID 21807755
    .
  8. S2CID 8746056
    .


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