Chlorzoxazone
Clinical data | |
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Trade names | Lorzone, Paraflex, Muscol |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682577 |
License data | |
Skeletal muscle relaxants | |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | Well absorbed |
Protein binding | 13–18% |
Metabolism | Hepatic |
Elimination half-life | 1.1 hours |
Duration of action | 3–4 hours |
Excretion | urine (<1%) |
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Chlorzoxazone (
It is available as a
Like metaxalone, its mechanism of action is still in question. It is believed that metaxalone works by altering serotonin levels and acting as a mild MAO inhibitor.[medical citation needed] The mechanism of action of chlorzoxazone is thought[by whom?] to act on GABAA and GABAB receptors and voltage-gated calcium channels to a degree.[medical citation needed] General central nervous system depression is the only currently accepted aspect to its medical benefits.[medical citation needed] Elucidation of the exact mechanism of action is ongoing but there is limited study due to the existence of more effective, safe muscle relaxants (e.g., diazepam, cyclobenzaprine, tizanidine), greatly limiting the potential benefit of identifying novel compounds which share chlorzoxazone's mechanism of action.
See also
References
- ^ "Parafon DSC- chlorzoxazone tablet". DailyMed. 9 February 2010. Retrieved 5 November 2020.
- ^ "Lorzone- chlorzoxazone tablet". DailyMed. 21 June 2019. Retrieved 5 November 2020.
- ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
Further reading
- Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF (2006). "Chlorzoxazone inhibit contraction of rat thoracic aorta". Eur J Pharmacol. 545 (2–3): 161–6. PMID 16859676.
- Park J, Kim K, Park P, Ha J (2006). "Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe". J Clin Pharmacol. 46 (1): 109–14. S2CID 20092326.
- Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats". J Pharm Pharmacol. 58 (1): 51–61. PMID 16393464.
External links
- "Chlorzoxazone". Drug Information Portal. U.S. National Library of Medicine.
- Chloroxazone Safety Data Sheet Archived 2019-07-12 at the Wayback Machine
- D.F. Marsh, U.S. patent 2,895,877 (1959)