Selank
 | This article needs additional citations for verification. (December 2010) |
 | |
| Clinical data | |
|---|---|
| Other names | Selanc; L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline |
| Routes of administration | Nasal muscosa, IV |
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
JSmol) | |
| |
| |
  (what is this?) (verify) | |
Selank (
sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It is a synthetic analogue of human tuftsin
.
Pharmacology
Selank is a synthetic analogue of the immunomodulatory peptide
monoamine neurotransmitters[2] and induce metabolism of serotonin.[3][4] Selank has also been found to rapidly elevate the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of rats.[5]
Selank, as well as a related peptide drug,
phenylmethylsulfonylfluoride-inhibited carboxypeptidase in rat nervous system tissue.[7]
Selank has been found to produce
Clinical trials
In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment of
benzodiazepines, as it has no sedating or negative cognitive side effects and no associated addiction
or withdrawal problems.
Selank is closely related to another nootropic drug, Semax, also developed by the Institute of Molecular Genetics in Russia. This drug is currently available in Russian and Ukrainian pharmacies.[9]
As with all
lyophilized
peptides, it needs refrigeration to remain stable within sterile water solutions, such as bacteriostatic water concentrations.
See also
References
- ^ PMID 18577961.
- PMID 19093364.
- PMID 20919548.
- PMID 19803361.
- S2CID 40709909.
- S2CID 26029820.
- PMID 22827026.
- PMID 18661785.
- ^ "СЕМАКС: лекарственное средство широкого спектра действия эффективный стимулятор нервной системы" [SEMAX: a broad-spectrum drug effective stimulant of the nervous system]. Institute of Molecular Genetics (in Russian). Moscow. Archived from the original on 2011-07-22.