Matrine

Source: Wikipedia, the free encyclopedia.
Matrine
Clinical data
ATC code
  • none
Legal status
Legal status
  • Unscheduled, sold OTC in US
Identifiers
  • (1R,2R,9S,17S)-7,13-Diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
JSmol)
SMILES
  • C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1
  • InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 ☒N
  • Key:ZSBXGIUJOOQZMP-JLNYLFASSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Matrine is an

in-vitro anti-cancer effects,[1] as well as κ-opioid and μ-opioid receptor agonism.[2][3]

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.[4] Matrine can be commercially extracted from the traditional Chinese medical herb Sophora flavescens Ait.

Mu opioid agonism is associated with

analgesia
when activated.

Matrine and the related compound

pine wilt,[6] as well as pathogenic nematodes which target humans.[7]

Matrine alleviates neuro-inflammation and oxidative stress in the brain caused by acute liver injury, thus producing antianxiety and antidepression effects.[8]

References

  1. PMID 19649719
    .
  2. S2CID 260280876
    .
  3. PMID 15863891
    .
  4. S2CID 260282269
    .
  5. PMID 17598549
    .
  6. doi:10.1021/jf00001a038
    .
  7. PMID 7200047
    .
  8. S2CID 73445828
    .
  • Media related to Matrine at Wikimedia Commons
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