Matrine

Matrine

Clinical data
ATC code	none
Legal status
Legal status	In general: unscheduled
Identifiers
IUPAC name (1R,2R,9S,17S)-7,13-Diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
JSmol)	Interactive image
SMILES C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1
InChI InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 N Key:ZSBXGIUJOOQZMP-JLNYLFASSA-N N
NY (what is this?)  (verify)

Matrine is an alkaloid found in plants from the genus Sophora. It has a variety of pharmacological effects, including anti-cancer effects,^[1] as well as κ-opioid and μ-opioid receptor agonism.^[2][3]

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.^[4] Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait.

Mu opioid agonism is associated with

Matrine and the related compound

Matrine alleviates neuro-inflammation and oxidative stress in the brain caused by acute liver injury, thus producing antianxiety and antidepression effects.[8]

References