Nufenoxole

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Nufenoxole
Identifiers
  • 2-[3-(2-azabicyclo[2.2.2]octan-2-yl)-1,1-diphenylpropyl]-5-methyl-1,3,4-oxadiazole
JSmol)
  • CC1=NN=C(O1)C(CCN2CC3CCC2CC3)(C4=CC=CC=C4)C5=CC=CC=C5
  • InChI=1S/C25H29N3O/c1-19-26-27-24(29-19)25(21-8-4-2-5-9-21,22-10-6-3-7-11-22)16-17-28-18-20-12-14-23(28)15-13-20/h2-11,20,23H,12-18H2,1H3
  • Key:CVOCKGAVXLCEGM-UHFFFAOYSA-N

Nufenoxole (SC-27166) is an

antidiarrhoeal drug which acts as a peripherally selective opioid agonist, in a similar manner to loperamide. while it is able to activate μ-opioid receptors, it fails to cross the blood–brain barrier and so has a selective action against diarrhoea without producing analgesic effects.[1][2][3][4][5]

See also

References

  1. ^ US RE29556E, Adelstein GW, "1,1-Diaryl-1-oxadiazol-alkylamines", issued 28 February 1978, assigned to G.D. Searle & Company 
  2. PMID 411912
    .
  3. PMID 200732
    .
  4. PMID 480185
    .
  5. S2CID 35222789
    .


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