Thienorphine
Source: Wikipedia, the free encyclopedia.
Chemical compound
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Thienorphine is a very potent, extremely long-acting, orally-active
affinity, balanced ligand of the μ- (Ki = 0.22 nM), δ- (Ki = 0.69 nM), and κ-opioid receptors (Ki = 0.14 nM), behaving as a partial agonist of the μ- (Emax = 19%–28%) and κ-opioid receptors (Emax = 65–75%) and as an antagonist of the δ-opioid receptor.[4][5][6] It also possesses relatively low affinity for the nociceptin receptor (Ki = 36.5 nM), where it acts as an antagonist.[6]
See also
References
Treatment of drug dependence (N07B) | |
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Nicotine dependence |
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Alcohol dependence |
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Opioid dependence | |
Benzodiazepine dependence |
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μ-opioid (MOR) |
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δ-opioid (DOR) |
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κ-opioid (KOR) |
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Nociceptin (NOP) |
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Others |
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