Isotonitazene

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Isotonitazene
Clinical data
Routes of
administration		By mouth, nasal spray, e-vape
Legal status
Legal status
Identifiers
  • N,N-diethyl-2-[2-[(4-isopropoxyphenyl)methyl]-5-nitro-benzimidazol-1-yl]ethanamine
JSmol)
  • CCN(CCn1c(Cc2ccc(cc2)OC(C)C)nc2c1ccc(c2)N(=O)=O)CC
  • InChI=1S/C23H30N4O3/c1-5-25(6-2)13-14-26-22-12-9-19(27(28)29)16-21(22)24-23(26)15-18-7-10-20(11-8-18)30-17(3)4/h7-12,16-17H,5-6,13-15H2,1-4H3
  • Key:OIOQREYBGDAYGT-UHFFFAOYSA-N

Isotonitazene is a benzimidazole-derived opioid analgesic drug related to etonitazene,[2][3][4] which has been sold as a designer drug.[5][6][7] It has only around half the potency of etonitazene in animal studies,[2][8][9][10][11][12][13] but it is likely even less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans).[2] Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While isotonitazene was not compared directly to morphine in this assay, it was found to be around 2.5 times more potent than hydromorphone and slightly more potent than fentanyl.[2][14]

Side effects

Side effects of benzimidazole derived opioids are likely to be similar to those of fentanyl, which include

respiratory depression, which can be life-threatening.[15]

Isotonitazene has been detected in multiple fatalities in Europe since March 2019[16] and in the U.S. since August 2019, as reported by NPS Discovery, the Center for Forensic Science Research and Education, and NMS Labs.[17][18]

Legal status

The US Drug Enforcement Administration issued a notice of intent to publish a temporary order to schedule isotonitazene in Schedule I of the Controlled Substances Act,[19] which came into effect on 20 August 2020.[20]

See also

References

  1. ^ Riksdagsförvaltningen. "Förordning (1992:1554) om kontroll av narkotika Svensk författningssamling 1992:1992:1554 t.o.m. SFS 2021:301 - Riksdagen". www.riksdagen.se (in Swedish).
  2. ^
    S2CID 208187034
    .
  3. S2CID 41516830
    .
  4. S2CID 232356192
    .
  5. ^ Power M (13 March 2020). "40 Americans Are Dying Every Month from Taking This New, Legal Opioid". Vice.
  6. S2CID 221939376
    .
  7. ^ Critical Review Report: Isotonitazene (PDF). Expert Committee on Drug Dependence, Forty-third Meeting. Geneva: World Health Organization. 12–20 October 2020. p. 7. Retrieved 20 May 2022. Street names: Iso; Nitazene; Toni.
  8. S2CID 32179439
    .
  9. doi:10.1002/hlca.19600430413
    .
  10. doi:10.1002/hlca.19600430515
    .
  11. doi:10.1002/hlca.19600430634
    .
  12. doi:10.1002/hlca.19610440513
    .
  13. S2CID 6824038
    .
  14. S2CID 220881657
    .
  15. PMID 37416459
    .
  16. S2CID 246776288
    .
  17. PMID 32091095
    .
  18. PMID 33234804
    .
  19. ^ "Schedules of Controlled Substances: Temporary Placement of Isotonitazene in Schedule I". Federal Register. 18 June 2020.
  20. ^ "Schedules of Controlled Substances: Temporary Placement of Isotonitazene in Schedule I". Federal Register. 20 August 2020.


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