Parafluorofentanyl

Source: Wikipedia, the free encyclopedia.
Parafluorofentanyl
Clinical data
Other names4-Fluorofentanyl; Para-fluorofentanyl; pFF
ATC code
  • none
Legal status
Legal status
Identifiers
  • N-(4-fluorophenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
JSmol)
  • Fc1ccc(cc1)N(C(=O)CC)C3CCN(CCc2ccccc2)CC3
  • InChI=1S/C22H27FN2O/c1-2-22(26)25(20-10-8-19(23)9-11-20)21-13-16-24(17-14-21)15-12-18-6-4-3-5-7-18/h3-11,21H,2,12-17H2,1H3 checkY
  • Key:KXUBAVLIJFTASZ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Parafluorofentanyl (4-fluorofentanyl, pFF) is an

analogue of fentanyl developed by Janssen Pharmaceuticals in the 1960s.[1]

4-Fluorofentanyl was sold briefly on the US black market in the early 1980s,[

Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared.[2] 4-Fluorofentanyl is made by the same synthetic route as fentanyl, but by substituting para-fluoroaniline for aniline in the synthesis.[3]

Side effects of

respiratory depression, which can be life-threatening. Fentanyl analogs have killed thousands of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[4]

In 2020, the Drug Enforcement Agency warned about the increasing prevalence of parafluorofentanyl in Arizona.[5][6]

See also

References

  1. ^ US patent 3164600 
  2. PMID 3286815
    .
  3. PMID 10945855
    .
  4. PMID 25976511
    .
  5. ^ "DEA warns of newly encountered fentanyl-like drug in Arizona". KNXV. December 28, 2020.
  6. ^ "DEA in Arizona warns of 'extremely dangerous' form of fentanyl". KTAR.com. December 29, 2020.
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