R-4066

R-4066

Clinical data
Other names	N-(3,3-diphenyl-4-oxohex-1-yl)-7,8-benzo-3-azaspiro[5.5]undecane
Identifiers
IUPAC name 6-{3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]-1'-yl}-4,4-diphenylhexan-3-one
JSmol)	Interactive image
SMILES CCC(=O)C(CCN1CCC2(CCCC3=CC=CC=C32)CC1)(C4=CC=CC=C4)C5=CC=CC=C5
InChI InChI=1S/C32H37NO/c1-2-30(34)32(27-14-5-3-6-15-27,28-16-7-4-8-17-28)22-25-33-23-20-31(21-24-33)19-11-13-26-12-9-10-18-29(26)31/h3-10,12,14-18H,2,11,13,19-25H2,1H3 N Key:ZVFXEHSJPKPKDW-UHFFFAOYSA-N N
NY (what is this?)  (verify)

R-4066 (Spirodone) is a drug which is an derivative of the opioid analgesic norpipanone, where the piperidino group has been replaced by a piperidinospiro group. Developed by Janssen Pharmaceutica,^[1] it is around 212× more potent than methadone as an analgesic in animal tests, with an effective oral dosage of 0.07 mg/kg, but is shorter acting, with a duration of action of around 3 hours. If the ketone function is reduced and acetylated, the racemate has a potency of 106× that of methadone and has an analgesic duration of 20.5 hours compared to 8 hours for methadone.^[2]

R-4066 has not been researched in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong

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