APRIL (protein)
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A proliferation-inducing ligand
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A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a
Nomenclature
In the cluster of differentiation terminology, APRIL is designated CD256.
Function
The protein encoded by this gene is a member of the
TNFRSF14/HVEM.[9]
Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Interactions
TNFSF13 has been shown to
Clinical significance
APRIL is being explored as a target for autoimmune diseases and B cell malignancies.[12] At least one anti-APRIL monoclonal antibody has been announced to enter phase I clinical trials for multiple myeloma.[13]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000161955 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089669 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9743536.
- ^ a b "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13". National Library of Medicine. 10 October 2023. Retrieved 13 October 2023.
- PMID 14729948.
- PMID 18180376.
- PMID 11550092.
- PMID 10956646.
- PMID 12370363.
- PMID 19760066.
- ^ "Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma". AACR 2017 Proceedings. April 2017.
Further reading
- Bossen C, Schneider P (October 2006). "BAFF, APRIL and their receptors: structure, function and signaling" (PDF). Seminars in Immunology. 18 (5): 263–75. PMID 16914324.
- Tangye SG, Bryant VL, Cuss AK, Good KL (October 2006). "BAFF, APRIL and human B cell disorders". Seminars in Immunology. 18 (5): 305–17. PMID 16916610.
- Treml LS, Crowley JE, Cancro MP (October 2006). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Seminars in Immunology. 18 (5): 297–304. PMID 16919470.
- Mackay F, Leung H (October 2006). "The role of the BAFF/APRIL system on T cell function". Seminars in Immunology. 18 (5): 284–9. PMID 16931039.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Shu HB, Hu WH, Johnson H (May 1999). "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens". Journal of Leukocyte Biology. 65 (5): 680–3. S2CID 1498303.
- Cousin P, Billotte J, Chaubert P, Shaw P (January 2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics. 63 (1): 60–8. PMID 10662545.
- Kelly K, Manos E, Jensen G, Nadauld L, Jones DA (February 2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Research. 60 (4): 1021–7. PMID 10706119.
- Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (November 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry. 275 (45): 35478–85. PMID 10956646.
- Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ, Sarosi I, Hsu H, Senaldi G, Theill LE (September 2000). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nature Immunology. 1 (3): 252–6. S2CID 6799584.
- López-Fraga M, Fernández R, Albar JP, Hahne M (October 2001). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Reports. 2 (10): 945–51. PMID 11571266.
- Stein JV, López-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodríguez D, Gómez-Caro R, De Jong J, Martínez-A C, Medema JP, Hahne M (June 2002). "APRIL modulates B and T cell immunity". The Journal of Clinical Investigation. 109 (12): 1587–98. PMID 12070306.
- Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, Casali P, Cerutti A (September 2002). "DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL". Nature Immunology. 3 (9): 822–9. PMID 12154359.
- Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, Stohl W, Baker KP, Ullrich S, Nardelli B, Hilbert DM, Migone TS (October 2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology. 169 (8): 4314–21. PMID 12370363.
- Pradet-Balade B, Medema JP, López-Fraga M, Lozano JC, Kolfschoten GM, Picard A, Martínez-A C, Garcia-Sanz JA, Hahne M (November 2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein". The EMBO Journal. 21 (21): 5711–20. PMID 12411489.
External links
- TNFSF13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human TNFSF13 genome location and TNFSF13 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.