CEACAM5
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| Location (UCSC) | Chr 19: 41.71 – 41.73 Mb | n/a | |||||||
| PubMed search | [2] | n/a | |||||||
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Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.[3]
Functions
In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.[4][5] Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.[6] Also, it plays a significant role in the inhibition of differentiation [7] and apoptosis [8] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.[9] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).[10][11]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105388 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".
- S2CID 10344352.
- PMID 32993395.
- S2CID 30740594.
- PMID 11896570.
- PMID 10910050.
- S2CID 235359543.
- S2CID 236398737.
- PMID 36923424.
Further reading
- Willcocks TC, Craig IW (November 1990). "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region". Genomics. 8 (3): 492–500. PMID 2286372.
- Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". Tumour Biology. 11 (1–2): 59–63. PMID 2309067.
- Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, et al. (June 1990). "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Molecular and Cellular Biology. 10 (6): 2738–2748. PMID 2342461.
- Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, et al. (August 1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5350–5354. PMID 2955415.
- Zimmermann W, Ortlieb B, Friedrich R, von Kleist S (May 1987). "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2960–2964. PMID 3033671.
- Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (July 1988). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics. 3 (1): 59–66. PMID 3220478.
- Zimmermann W, Weber B, Ortlieb B, Rudert F, Schempp W, Fiebig HH, et al. (May 1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Research. 48 (9): 2550–2554. PMID 3356015.
- Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP (September 1987). "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Molecular and Cellular Biology. 7 (9): 3221–3230. PMID 3670312.
- Oikawa S, Nakazato H, Kosaki G (January 1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochemical and Biophysical Research Communications. 142 (2): 511–518. PMID 3814146.
- PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. PMID 9373149.
- Hart SP, Ross JA, Ross K, Haslett C, Dransfield I (May 2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death and Differentiation. 7 (5): 493–503. PMID 10800083.
- Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL (June 2000). "Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells". Infection and Immunity. 68 (6): 3554–3563. PMID 10816511.
- Boehm MK, Perkins SJ (June 2000). "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Letters. 475 (1): 11–16. S2CID 5765612.
- Screaton RA, DeMarte L, Dráber P, Stanners CP (August 2000). "The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor". The Journal of Cell Biology. 150 (3): 613–626. PMID 10931872.
- Bajenova OV, Zimmer R, Stolper E, Salisbury-Rowswell J, Nanji A, Thomas P (August 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". The Journal of Biological Chemistry. 276 (33): 31067–31073. PMID 11406629.
- Wirth T, Soeth E, Czubayko F, Juhl H (2002). "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clinical & Experimental Metastasis. 19 (2): 155–160. S2CID 3138022.
- Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C (October 2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". International Journal of Cancer. 101 (6): 545–548. S2CID 7030523.
- Hampton R, Walker M, Marshall J, Juhl H (November 2002). "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene. 21 (51): 7817–7823. PMID 12420218.
External links
- CEACAM5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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