NCR2

NCR2
	Gene ontology
Molecular function	transmembrane signaling receptor activity; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell surface;
Biological process	cellular defense response; innate immune response; signal transduction; regulation of immune response; regulation of innate immune response;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000096264


n/a

UniProt


O95944


n/a

RefSeq (mRNA)


NM_004828 NM_001199509 NM_001199510


n/a

RefSeq (protein)


NP_001186438 NP_001186439 NP_004819


n/a

Location (UCSC)

Chr 6: 41.34 – 41.35 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene.^[3]^[4] NCR2 has also been designated as CD336 (cluster of differentiation 336), NKp44, NKP44; NK-p44, LY95, and dJ149M18.1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000096264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 10049942
.

^ "Entrez Gene: NCR2 natural cytotoxicity triggering receptor 2".

^ "NCR2 natural cytotoxicity triggering receptor 2 [Homo sapiens (human)] - Gene - NCBI".

Further reading

Hershkovitz O, Jivov S, Bloushtain N, et al. (2007). "Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44". Biochemistry. 46 (25): 7426–36.
PMID 17536787
.

Forte P, Lilienfeld BG, Baumann BC, Seebach JD (2005). "Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D". J. Immunol. 175 (8): 5463–70.
PMID 16210654
.

Fuchs A, Cella M, Kondo T, Colonna M (2005). "Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44". Blood. 106 (6): 2076–82.
PMID 15941912
.

Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60.
PMID 15728472
.

Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22.
PMID 15657183
.

Campbell KS, Yusa S, Kikuchi-Maki A, Catina TL (2004). "NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence". J. Immunol. 172 (2): 899–906.
PMID 14707061
.

Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11.
PMID 14574404
.

Cantoni C, Ponassi M, Biassoni R, et al. (2004). "The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity". Structure. 11 (6): 725–34.
PMID 12791260
.

Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41.
S2CID 10724743
.

Allcock RJ, Barrow AD, Forbes S, et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". Eur. J. Immunol. 33 (2): 567–77.
S2CID 27147251
.

Cantoni C, Ponassi M, Biassoni R, et al. (2003). "Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44". Acta Crystallogr. D. 58 (Pt 10 Pt 2): 1843–5.
PMID 12351833
.

External links

NCR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

PDBe-KB provides an overview of all the structure information available in the PDB for Human Natural cytotoxicity triggering receptor 2 (NCR2)

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PDB gallery

1hkf: THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY

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Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50

CD1
a-c

1A

1B

1D

1E

CD2

CD3
γ

δ

ε

CD4

CD5

CD6

CD7

CD8
a

CD9

CD10

CD11
a

b

c

d

CD13

CD14

CD15

CD16
A

B

CD18

CD19

CD20

CD21

CD22

CD23

CD24

CD25

CD26

CD27

CD28

CD29

CD30

CD31

CD32
A

B

CD33

CD34

CD35

CD36

CD37

CD38

CD39

CD40

CD41

CD42
a

b

c

d

CD43

CD44

CD45

CD46

CD47

CD48

CD49
a

b

c

d

e

f

CD50

51–100

CD51

CD52

CD53

CD54

CD55

CD56

CD57

CD58

CD59

CD61

CD62
E

L

P

CD63

CD64
A

B

C

CD66
a

b

c

d

e

f

CD68

CD69

CD70

CD71

CD72

CD73

CD74

CD78

CD79
a

b

CD80

CD81

CD82

CD83

CD84

CD85
a

d

e

h

j

k

CD86

CD87

CD88

CD89

CD90

CD92

CD93

CD94

CD95

CD96

CD97

CD98

CD99

CD100

101–150

CD101

CD102

CD103

CD104

CD105

CD106

CD107
a

b

CD108

CD109

CD110

CD111

CD112

CD113

CD114

CD115

CD116

CD117

CD118

CD119

CD120
a

b

CD121
a

b

CD122

CD123

CD124

CD125

CD126

CD127

CD129

CD130

CD131

CD132

CD133

CD134

CD135

CD136

CD137

CD138

CD140b

CD141

CD142

CD143

CD144

CD146

CD147

CD148

CD150

151–200

CD151

CD152

CD153

CD154

CD155

CD156
a

b

c

CD157

CD158 (a

d

e

i

k)

CD159
a

c

CD160

CD161

CD162

CD163

CD164

CD166

CD167
a

b

CD168

CD169

CD170

CD171

CD172
a

b

g

CD174

CD177

CD178

CD179
a

b

CD180

CD181

CD182

CD183

CD184

CD185

CD186

CD191

CD192

CD193

CD194

CD195

CD196

CD197

CDw198

CDw199

CD200

201–250

CD201

CD202b

CD204

CD205

CD206

CD207

CD208

CD209

CDw210
a

b

CD212

CD213a
1

2

CD217

CD218 (a

b)

CD220

CD221

CD222

CD223

CD224

CD225

CD226

CD227

CD228

CD229

CD230

CD233

CD234

CD235
a

b

CD236

CD238

CD239

CD240CE

CD240D

CD241

CD243

CD244

CD246

CD247 - CD248

CD249

251–300

CD252

CD253

CD254

CD256

CD257

CD258

CD261

CD262

CD263

CD264

CD265

CD266

CD267

CD268

CD269

CD271

CD272

CD273

CD274

CD275

CD276

CD278

CD279

CD280

CD281

CD282

CD283

CD284

CD286

CD288

CD289

CD290

CD292

CDw293

CD294

CD295

CD297

CD298

CD299

301–350

CD300A

CD301

CD302

CD303

CD304

CD305

CD306

CD307

CD309

CD312

CD314

CD315

CD316

CD317

CD318

CD320

CD321

CD322

CD324

CD325

CD326

CD327

CD328

CD329

CD331

CD332

CD333

CD334

CD335

CD336

CD337

CD338

CD339

CD340

CD344

CD349

CD350

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Retrieved from "https://en.wikipedia.org/w/index.php?title=NCR2&oldid=1032162490"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000096264 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10049942-3] PMID 10049942
.

[entrez-4] "Entrez Gene: NCR2 natural cytotoxicity triggering receptor 2".

[5] "NCR2 natural cytotoxicity triggering receptor 2 [Homo sapiens (human)] - Gene - NCBI".

[2]

[3]

[4]

[5]