Basal cell adhesion molecule
| BCAM | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 44.81 – 44.82 Mb | Chr 7: 19.49 – 19.5 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Basal cell adhesion molecule, also known as plasma membrane glycoprotein that in humans is encoded by the BCAM gene.[5] BCAM has also recently been designated CD239 (cluster of differentiation 239).
Function
Lutheran blood group glycoprotein is a member of the
C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.[5]
Interactions
BCAM has been shown to
interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.[6][7][8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000187244 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002980 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)".
- S2CID 10715366.
- PMID 12244066.
- PMID 36647260.
Further reading
- Eyler CE, Telen MJ (2006). "The Lutheran glycoprotein: a multifunctional adhesion receptor". Transfusion. 46 (4): 668–77. S2CID 37594599.
- Lewis M, Kaita H, Coghlan G, et al. (1989). "The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man". Ann. Hum. Genet. 52 (Pt 2): 137–44. S2CID 26927877.
- Parsons SF, Mallinson G, Holmes CH, et al. (1995). "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5496–500. PMID 7777537.
- Campbell IG, Foulkes WD, Senger G, et al. (1994). "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily". Cancer Res. 54 (22): 5761–5. PMID 7954395.
- Rahuel C, Le Van Kim C, Mattei MG, et al. (1996). "A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein". Blood. 88 (5): 1865–72. PMID 8781446.
- Parsons SF, Mallinson G, Daniels GL, et al. (1997). "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms". Blood. 89 (11): 4219–25. PMID 9166867.
- El Nemer W, Rahuel C, Colin Y, et al. (1997). "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism". Blood. 89 (12): 4608–16. PMID 9192786.
- Parsons SF, Lee G, Spring FA, et al. (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. S2CID 10715366.
- El Nemer W, Gane P, Colin Y, et al. (2001). "Characterization of the laminin binding domains of the Lutheran blood group glycoprotein". J. Biol. Chem. 276 (26): 23757–62. PMID 11319237.
- Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2003). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. PMID 12244066.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. PMID 12493773.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. S2CID 581283.
- Crew VK, Green C, Daniels G (2004). "Molecular bases of the antigens of the Lutheran blood group system". Transfusion. 43 (12): 1729–37. S2CID 23121476.
- Zen Q, Batchvarova M, Twyman CA, et al. (2004). "B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease". Am. J. Hematol. 75 (2): 63–72. S2CID 25313713.
- Kroviarski Y, El Nemer W, Gane P, et al. (2004). "Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin". Br. J. Haematol. 126 (2): 255–64. S2CID 27161744.
- Drewniok C, Wienrich BG, Schön M, et al. (2005). "Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer". Arch. Dermatol. Res. 296 (2): 59–66. S2CID 20724995.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. S2CID 13047538.
- Sivakumar S, Lieber S, Librizzi D, et al. (2023). "Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer". Clin Transl Med. 13 (1): e1176. PMID 36647260.
- Vainionpää N, Kikkawa Y, Lounatmaa K, et al. (2006). "Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells". Am. J. Physiol., Cell Physiol. 290 (3): C764–75. PMID 16236823.
External links
- BCAM+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human BCAM genome location and BCAM gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |