Integrin alpha 2
(Redirected from
CD49b
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| Location (UCSC) | Chr 5: 52.99 – 53.09 Mb | Chr 13: 114.97 – 115.07 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.
The CD49b protein is an
platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.[5]
Expression of CD49b in conjunction with
type 1 regulatory (Tr1) cells.[6]
The DX5
monoclonal antibody recognizes mouse CD49b.[7]
Interactions
CD49b has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164171 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015533 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".
- S2CID 21305032.
- PMID 11466327.
- PMID 11359774.
- PMID 11359786.
External links
- CD49b+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha 2
Further reading
- Moroi M, Jung SM (1997). "Platelet receptors for collagen". Thromb. Haemost. 78 (1): 439–44. S2CID 8121197.
- Takada Y, Kamata T, Irie A, Puzon-McLaughlin W, Zhang XP (1998). "Structural basis of integrin-mediated signal transduction". Matrix Biol. 16 (4): 143–51. PMID 9402003.
- Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins". Cell. Mol. Life Sci. 54 (6): 556–66. S2CID 9775686.
- Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. PMID 9789327.
- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. PMID 12482545.
- Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22. PMID 12690916.
- Tsantes AE, Nikolopoulos GK, Bagos PG, Vaiopoulos G, Travlou A (2007). "Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis". Int. J. Cardiol. 118 (2): 189–96. PMID 17023078.
External links
- ITGA2 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGA2 genome location and ITGA2 gene details page in the UCSC Genome Browser.
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