JM-1232

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JM-1232
Identifiers
  • (3R)-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f]isoindol-1-one
JSmol)
  • O=C1C2=CC3=C(C=C2[C@H](N1C4=CC=CC=C4)CC(N5CCN(CC5)C)=O)CCC3
  • InChI=1S/C24H27N3O2/c1-25-10-12-26(13-11-25)23(28)16-22-20-14-17-6-5-7-18(17)15-21(20)24(29)27(22)19-8-3-2-4-9-19/h2-4,8-9,14-15,22H,5-7,10-13,16H2,1H3/t22-/m1/s1 ☒N
  • Key:MBGOHVUPIPFVMM-JOCHJYFZSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.[1][2][3][4][5][6] It was developed by a team at Maruishi Pharmaceutica.[7]

A human study explored the sedation caused by infusions at a range of doses, finding a fair hemodynamic safety profile.[8]

References

  1. PMID 18057740
    .
  2. PMID 18708047
    .
  3. S2CID 22569204
    .
  4. S2CID 44392251
    .
  5. PMID 20217332
    .
  6. PMID 20650920
    .
  7. ^ EP 1566378, Toyooka K, Kanamitsu N, Yoshimura M, Kuriyama H, Tamura T, "Isoindoline Derivative", issued 15 August 2012, assigned to Maruishi Pharmaceutical Co Ltd. 
  8. PMID 22222479
    .
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