Safranal

Safranal

Names
Preferred IUPAC name 2,6,6-Trimethylcyclohexa-1,3-diene-1-carbaldehyde
Identifiers
CAS Number	116-26-7 N
3D model ( JSmol )	Interactive image
ChEBI	CHEBI:53169 Y
ChemSpider	55000 Y
ECHA InfoCard	100.003.758
PubChem CID	61041
UNII	4393FR07EA Y
CompTox Dashboard (EPA)	DTXSID7049398
InChI InChI=1S/C10H14O/c1-8-5-4-6-10(2,3)9(8)7-11/h4-5,7H,6H2,1-3H3 Y Key: SGAWOGXMMPSZPB-UHFFFAOYSA-N Y
SMILES O=C\C1=C(\C=C/CC1(C)C)C
Properties
Chemical formula	C10H14O
Molar mass	150.21 g/mol
Density	0.9734 g/cm3
Boiling point	70 °C (158 °F; 343 K) at 1 mmHg
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Safranal is an

It is believed that safranal is a degradation product of the carotenoid zeaxanthin via the intermediate picrocrocin.

Pharmacology

Safranal is an effective anticonvulsant in animal models, shown to act as an agonist at GABA_A receptors.^[1][2] Safranal also exhibits high antioxidant and free radical scavenging activity,^[3][4] along with cytotoxicity towards cancer cells in vitro.^[5] One of its anticancer mechanisms of action involves disruption of the normal assembly dynamics of cellular microtubules.^[6] It has also been shown to have antidepressant properties in animals and pilot studies in humans.^[7][8]

Natural sources

Natural sources of safranal include:^{[9][unreliable source?]}

• Microcystis (cyanobacterium)
• Aspalathus linearis
  (Rooibos)
• Camellia sinensis (Tea leaf)
• Crocus sativus (Saffron)
• Ficus carica
  (Fig leaf)
• Lycium chinense (Wolfberry)
• Cuminum cyminum (Cumin Seed)^[10]
• Centaurea sibthorpii ^[11]
• Centaurea amanicola^[11]
• Centaurea consanguinea^[11]
• Erodium cicutarium (common stork's-bill or pinweed)^[11]
• Calycopteris floribunda (Ukshi)^[11]
• Sambucus nigra (elderberry)^[11]
• Citrus limon (lemon)^[11]
• Achillea distans ^[11]

References