SX-3228

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SX-3228
Clinical data
Other names5,6,7,8-tetrahydro-3-(5-methoxy-1,3,4-oxadiazol-2-yl)-6-(phenylmethyl)-1,6-naphthyridin-2(1H)-one
Identifiers
  • (3E)-6-benzyl-3-(5-methoxy-1,3,4-oxadiazol-2(3H)-ylidene)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(3H)-one
JSmol)
  • COc1nnc(o1)C/3=C/C=4CN(Cc2ccccc2)CCC=4NC\3=O
  • InChI=1S/C18H18N4O3/c1-24-18-21-20-17(25-18)14-9-13-11-22(8-7-15(13)19-16(14)23)10-12-5-3-2-4-6-12/h2-6,9H,7-8,10-11H2,1H3,(H,19,23) checkY
  • Key:BZLLVTYOOJNQIF-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.

SX-3228 is a subtype-selective

positive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies.[1][2] It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation.[3][4]

References

  1. S2CID 42758930
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  2. PMID 10780255
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  3. S2CID 269304
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  4. PMID 10454763
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