Benidipine

Source: Wikipedia, the free encyclopedia.
Benidipine
Skeletal formula of benidipine
Ball-and-stick model of the benidipine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATC code
Identifiers
  • O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
JSmol)
  • [O-][N+](=O)c1cccc(c1)[C@@H]4C(/C(=O)OC)=C(\N\C(=C4\C(=O)O[C@@H]3CCCN(Cc2ccccc2)C3)C)C
  • InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1 ☒N
  • Key:QZVNQOLPLYWLHQ-ZEQKJWHPSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Benidipine is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). It is a triple L-, T-, and N-type calcium channel blocker. It is reno- and cardioprotective.

It was patented in 1981 and approved for medical use in 1991.[1]

Dosing

Benidipine is dosed as 2–8 mg once daily.[2]

Mechanism

Benidipine is a calcium channel blocker.

Benidipine has additionally been found to act as an

antimineralocorticoid.[3]

Names

Other names include Benidipinum or benidipine hydrochloride.

Benidipine is sold as Coniel by Kyowa Hakko Kogyo.

Benidipine is initially licensed for use in Japan and selected

Southeast Asian
countries and later in Turkey, where it is sold as 4 mg tablets.

References

  1. ISBN 9783527607495
    .
  2. ^ Hi-Eisai Pharmaceutical, Inc. "Coniel (benidipine) package insert (Philippines)". MIMS Philippines. CMPMedica. Retrieved 2008-03-31.
  3. PMID 24992570
    .