Chloride channel blocker
A chloride channel blocker is a type of drug which inhibits the transmission of ions (Cl−) through chloride channels.
scientific research.[1] Another example is anthracene-9-carboxylic acid, a potent blocker of the CLCN1-type chloride channel found in skeletal muscle, which is used to study animal models of myotonia congenita.[2]
Some antagonists of
GABAA receptors
also act as chloride channel blockers.
See also
References
Further reading
- Phillis JW, Song D, O'Regan MH (January 1998). "Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex". Brain Research. 780 (2): 352–5. S2CID 3160962.
- Zhou, Yuhong; Shapiro, Michael; Dong, Qu; Louahed, Jamila; Weiss, Christine; Wan, Shanhong; Chen, Qiming; Dragwa, Carl; Savio, Dawn; Huang, Minxue; Fuller, Catherine; Tomer, Yaniv; Nicolaides, Nicholas C.; McLane, Michael; Levitt, Roy C. (2002). "A Calcium‐Activated Chloride Channel Blocker Inhibits Goblet Cell Metaplasia and Mucus Overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–170. ISBN 9780470844786.
- Mohamed F, Senarathna L, Percy A, Abeyewardene M, Eaglesham G, Cheng R, Azher S, Hittarage A, Dissanayake W, Sheriff MH, Davies W, Buckley NA, Eddleston M (2004). "Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil--a GABAA-gated chloride channel blocker". Journal of Toxicology. Clinical Toxicology. 42 (7): 955–63. PMID 15641641.
- Lukacs GL, Nanda A, Rotstein OD, Grinstein S (August 1991). "The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells". FEBS Letters. 288 (1–2): 17–20. S2CID 35959479.
- Kang JX, Man SF, Brown NE, Labrecque PA, Clandinin MT (August 1992). "The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells". The Biochemical Journal. 285 ( Pt 3) (3): 725–9. PMID 1323271.
- Liu J, Lai ZF, Wang XD, Tokutomi N, Nishi K (April 1998). "Inhibition of sodium current by chloride channel blocker 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) in guinea pig cardiac ventricular cells". Journal of Cardiovascular Pharmacology. 31 (4): 558–67. PMID 9554805.
 | This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |