Integrin beta 3
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| Location (UCSC) | Chr 17: 47.25 – 47.31 Mb | Chr 11: 104.5 – 104.56 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Integrin beta-3 (β3) or CD61 is a
thrombocytes.[6]
Structure and function
The ITGB3 protein product is the integrin beta chain beta 3.
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[7]
Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.[8]
Interactions
CD61 has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000259207 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020689 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 2454952.
- S2CID 206157070.
- ^ "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".
- PMID 21672902.
- PMID 11927607.
- PMID 9169439.
- PMID 11864709.
- PMID 7593198.
- PMID 10497223.
- PMID 11932255.
- PMID 9030514.
Further reading
- Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.
- Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci. 936 (1): 340–54. S2CID 25431334.
- Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.
- Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. PMID 12637342.
- Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22. PMID 12690916.
- Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thromb. Res. 112 (4): 209–16. PMID 14987913.
- Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): 1567–76. PMID 15134555.
- Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730.
- Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". J. Thromb. Haemost. 3 (8): 1752–62. S2CID 42666713.
- Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3". J. Clin. Invest. 115 (12): 3363–9. PMID 16322781.
External links
- CD61+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGB3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.
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