Ketocaine

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Ketocaine
Clinical data
ATC code
  • None
Identifiers
  • 1-[2-[2-[di(propan-2-yl)amino]ethoxy]phenyl]butan-1-one
JSmol)
  • CCCC(=O)C1=CC=CC=C1OCCN(C(C)C)C(C)C
  • InChI=InChI=1S/C18H29NO2/c1-6-9-17(20)16-10-7-8-11-18(16)21-13-12-19(14(2)3)15(4)5/h7-8,10-11,14-15H,6,9,12-13H2,1-5H3
  • Key:UXAWFWFJXIANHZ-UHFFFAOYSA-N

Ketocaine (

pain relief. It is marketed in Italy.[1][2][3]

Synthesis

Synthesis:[4] Patent:[5] Prec

Williamson ether synthesis between 2'-hydroxybutyrophenone [2887-61-8] (1) and diisopropylaminoethyl chloride hydrochloride [4261-68-1] (2) gives Ketocaine (3)..

References

  1. ISBN 978-1-4757-2085-3. Archived
    from the original on 10 January 2023. Retrieved 3 October 2016.
  2. ISBN 978-94-011-4439-1
    .
  3. ISBN 978-0-13-656372-3
    .
  4. ^ Da Re, Paolo.; Verlicchi, Lucia.; Setnikar, Ivo. (1967). "β-Phenoxyethylamines with Local Anesthetic and Antispasmodic Activity". Journal of Medicinal Chemistry. 10 (2): 266–270. doi:10.1021/jm00314a036.
  5. ^ Re Paolo Da, Setnikar Ivo, U.S. patent 3,335,184 (1967 to S Chemiques Et Pharma Seceph S).