Zoxazolamine

Source: Wikipedia, the free encyclopedia.
Zoxazolamine
Clinical data
Other namesMcN-485
Routes of
administration		Oral
Identifiers
  • 5-Chloro-1,3-benzoxazol-2-amine
JSmol)
  • C1=CC2=C(C=C1Cl)N=C(O2)N
  • InChI=InChI=1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10)
  • Key:YGCODSQDUUUKIV-UHFFFAOYSA-N

Zoxazolamine (

INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed.[1][2] It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity.[1][2][3] One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine.[3] These drugs activate IKCa channels.[4]

References

  1. ^
    ISBN 978-1-4757-2085-3
    .
  2. ^
    ISBN 978-81-224-1565-0
    .
  3. ^
    ISBN 978-1-4684-3444-6
    .
  4. ISBN 978-3-540-38916-3
    .