Interleukin 8 receptor, alpha

CXCR1
Gene ontology
Molecular function	C-X-C chemokine receptor activity interleukin-8 binding G protein-coupled receptor activity chemokine receptor activity interleukin-8 receptor activity signal transducer activity C-C chemokine receptor activity chemokine binding C-C chemokine binding
Cellular component	integral component of membrane plasma membrane secretory granule membrane membrane external side of plasma membrane
Biological process	G protein-coupled receptor signaling pathway cell surface receptor signaling pathway receptor internalization dendritic cell chemotaxis signal transduction chemokine-mediated signaling pathway interleukin-8-mediated signaling pathway neutrophil degranulation chemotaxis immune response positive regulation of cytosolic calcium ion concentration calcium-mediated signaling neutrophil chemotaxis cell chemotaxis
Sources:Amigo / QuickGO

Ensembl				ENSG00000163464	ENSMUSG00000048480
UniProt	P25024	Q810W6
RefSeq (mRNA)	NM_000634	NM_178241
RefSeq (protein)	NP_000625	NP_839972
Location (UCSC)	Chr 2: 218.16 – 218.17 Mb	Chr 1: 74.23 – 74.23 Mb
PubMed search	[3]	[4]

Wikidata

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Interleukin 8 receptor, alpha is a

Committee on Receptor Nomenclature and Drug Classification use the HGNC recommended name, CXCR1.

Function

The protein encoded by this gene is a member of the

Clinical significance

Blocking CXCR1 (e.g., with repertaxin^[7]) inhibits some human breast cancer stem cells (in vitro and in mice).^[8]

In malignant melanoma expression of CXCR1 at the cell surface is present, independent of the cancers stage. It is thought to have a role in the cell growth and angiogenesis required for tumour survival. In this way it has been identified as a potential therapeutic target.^[9]

CXCR1 can be cleaved and inactivated by Neutrophil Derived Serine Proteases (NSPs), leading to neutrophil dysfunction and impaired bacterial killing in cystic fibrosis lung disease.^[10]

Interactions

Interleukin 8 receptor, alpha has been shown to

See also

• Interleukin
• Interleukin 8
• Interleukin 8 receptor, beta
• Interleukin receptor
• Interleukin-8 receptor

References

Further reading

• Ahuja SK, Ozçelik T, Milatovitch A, Francke U, Murphy PM (1992). "Molecular evolution of the human interleukin-8 receptor gene cluster". Nat. Genet. 2 (1): 31–6.
  S2CID 19732372
  .
• Lee J, Horuk R, Rice GC, Bennett GL, Camerato T, Wood WI (1992). "Characterization of two high affinity human interleukin-8 receptors". J. Biol. Chem. 267 (23): 16283–7.
  PMID 1379593
  .
• Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics. 14 (3): 685–91.
  PMID 1427896
  .
• Holmes WE, Lee J, Kuang WJ, Rice GC, Wood WI (1991). "Structure and functional expression of a human interleukin-8 receptor". Science. 253 (5025): 1278–80.
  PMID 1840701
  .
• Chuntharapai A, Lee J, Hébert CA, Kim KJ (1994). "Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes". J. Immunol. 153 (12): 5682–8.
  S2CID 8872590
  .
• Chuntharapai A, Kim KJ (1995). "Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptor". J. Immunol. 155 (5): 2587–94.
  S2CID 24746695
  .
• Morohashi H, Miyawaki T, Nomura H, Kuno K, Murakami S, Matsushima K, Mukaida N (1995). "Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells". J. Leukoc. Biol. 57 (1): 180–7.
  S2CID 7819367
  .
• Schönbeck U, Brandt E, Petersen F, Flad HD, Loppnow H (1995). "IL-8 specifically binds to endothelial but not to smooth muscle cells". J. Immunol. 154 (5): 2375–83.
  S2CID 31884586
  .
• Ahuja SK, Shetty A, Tiffany HL, Murphy PM (1994). "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B". J. Biol. Chem. 269 (42): 26381–9.
  PMID 7929358
  .
• Sprenger H, Lloyd AR, Meyer RG, Johnston JA, Kelvin DJ (1994). "Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene". J. Immunol. 153 (6): 2524–32.
  S2CID 12014231
  .
• Schnitzel W, Monschein U, Besemer J (1994). "Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B". J. Leukoc. Biol. 55 (6): 763–70.
  S2CID 5948202
  .
• Wu D, LaRosa GJ, Simon MI (1993). "G protein-coupled signal transduction pathways for interleukin-8". Science. 261 (5117): 101–3.
  PMID 8316840
  .
• Sebok K, Woodside D, al-Aoukaty A, Ho AD, Gluck S, Maghazachi AA (1993). "IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein". J. Immunol. 150 (4): 1524–34.
  S2CID 29083621
  .
• Cerretti DP, Kozlosky CJ, Vanden Bos T, Nelson N, Gearing DP, Beckmann MP (1993). "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2". Mol. Immunol. 30 (4): 359–67.
  PMID 8384312
  .
• Mollereau C, Muscatelli F, Mattei MG, Vassart G, Parmentier M (1993). "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor". Genomics. 16 (1): 248–51.
  PMID 8486366
  .
• Lloyd A, Modi W, Sprenger H, Cevario S, Oppenheim J, Kelvin D (1993). "Assignment of genes for interleukin-8 receptors (IL8R) A and B to human chromosome band 2q35". Cytogenet. Cell Genet. 63 (4): 238–40.
  PMID 8500355
  .
• Damaj BB, McColl SR, Mahana W, Crouch MF, Naccache PH (1996). "Physical association of Gi2alpha with interleukin-8 receptors". J. Biol. Chem. 271 (22): 12783–9.
  PMID 8662698
  .
• Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50.
  PMID 8702798
  .
• Damaj BB, McColl SR, Neote K, Songqing N, Ogborn KT, Hébert CA, Naccache PH (1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops". FASEB J. 10 (12): 1426–34.
  S2CID 9744575
  .
• Jerva LF, Sullivan G, Lolis E (1997). "Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes". Protein Sci. 6 (8): 1643–52.
  PMID 9260277
  .

External links

• "Chemokine Receptors: CXCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-03.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.