Two-pore-domain potassium channel
(Redirected from
Tandem pore domain potassium channel
)The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess
G-proteins.[2] Two-pore-domain potassium channels correspond structurally to a inward-rectifier potassium channel α-subunits. Each inward-rectifier potassium channel α-subunit is composed of two transmembrane α-helices, a pore helix and a potassium ion selectivity filter sequence and assembles into a tetramer forming the complete channel.[3] The two-pore domain potassium channels instead are dimers where each subunit is essentially two α-subunits joined together.[4]
Each single channel does not have two pores; the name of the channel comes from the fact that each subunit has two P (pore) domains in its primary sequence.[5] To quote Rang and Dale (2015), "The nomenclature is misleading, especially when they are incorrectly referred to as two-pore channels".[6]
Below is a list of the 15 known two-pore-domain human potassium channels:[1]
| Gene | Channel[7] | Family | Aliases |
| KCNK1 | K2p1.1 | TWIK[2][8] | TWIK-1 |
| KCNK2 | K2p2.1 | TREK[2][8] | TREK-1 |
| KCNK3 | K2p3.1 | TASK[2][8] | TASK-1 |
| KCNK4 | K2p4.1 | TREK[2][8] | TRAAK[9] |
| KCNK5 | K2p5.1 | TASK[2][8] | TASK-2[10] |
| KCNK6 | K2p6.1 | TWIK[2][8] | TWIK-2 |
| KCNK7 | K2p7.1 | TWIK[2][8] | |
| KCNK9 | K2p9.1 | TASK[2][8] | TASK-3 |
| KCNK10 | K2p10.1 | TREK[2][8] | TREK-2 |
| KCNK12 | K2p12.1 | THIK | THIK-2 |
| KCNK13 | K2p13.1 | THIK | THIK-1 |
| KCNK15 | K2p15.1 | TASK[2][8] | TASK-5 |
| KCNK16 | K2p16.1 | TALK[2][8] | TALK-1 |
| KCNK17 | K2p17.1 | TALK[2][8] | TALK-2, TASK-4 |
| KCNK18 | K2p18.1 | TRIK, TRESK[2][8][11][12] |
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See also
References
- ^ S2CID 7356601.
- ^ PMID 20393194.
- PMID 9525859.
- S2CID 206537279.
- ^ Baggetta AM, Bayliss DA, Czirják G, Enyedi P, Goldstein SA, Lesage F, Minor Jr DL, Plant LD, Sepúlveda F. "Two P domain potassium channels". GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology. Retrieved 2019-05-28.
- ISBN 978-0-443-07145-4.
- S2CID 34963430.
- ^ S2CID 12759521.
- PMID 9628867.
- S2CID 9682396.
- PMID 12754259.
- PMID 14981085.
External links
- Tandem+Pore+Domain+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- "Two-P Potassium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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