LRRK2 G2019S accounts for parkinsonism in several families[1]
There is a functional interaction between LRRK2 and ADP-ribosylation factor GTPase-activating protein 1 (ArfGAP1)[2]
Unlike other known genetic causes of parkinsonism, G2019S LRRK2 mutation causes late onset disease[3]
G2019S LRRK2 mutation is associated with Lewy body formation which is also characteristic of most cases of Parkinson disease[4]
PARK8-causing mutations in LRRK2. Some of the first identified individuals with these mutation were of Basque descent so the protein was called "dardarin" after the Basque word ("dardara") for "tremor".[5]
