RTI-32

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RTI-32
Identifiers
  • Methyl (1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
JSmol)
  • CC1=CC=C(C=C1)[C@H]2C[C@@H]3CC[C@H]([C@H]2C(=O)OC)N3C
  • InChI=1S/C17H23NO2/c1-11-4-6-12(7-5-11)14-10-13-8-9-15(18(13)2)16(14)17(19)20-3/h4-7,13-16H,8-10H2,1-3H3/t13-,14+,15+,16-/m0/s1
  • Key:MMKZDDDDODERSJ-JJXSEGSLSA-N
  (verify)

(–)-2β-Carbomethoxy-3β-(4-

tolyl)tropane (RTI-4229-32, tolpane) is a phenyltropane-based cocaine analogue that has similar properties in vitro to related drugs such as RTI-31.[1][2]

Comparison of Data
Compound DAT DA NET NA SERT 5HT ED50
Troparil 23 49.8 550 37.2 178 173 0.34
RTI-32 1.7 7.02 36 8.42 23 19.4 0.31
RTI-31 1.1 3.68 22 5.86 4.0 5.0 0.13
3'4'-
xylyl
 0.43 unknown 44 unknown 2.42 unknown

See also

References

  1. PMID 15716302
    .
  2. PMID 11881989
    .
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