2-Aminotetralin

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2-Aminotetralin
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 1,2,3,4-tetrahydronaphthalen-2-amine
JSmol)
SMILES
  • C1CC2=CC=CC=C2CC1N
  • InChI=1S/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4,10H,5-7,11H2 checkY
  • Key:LCGFVWKNXLRFIF-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin group combined with an amine.[1][2]

2-AT is a rigid

7-ABTooltip 7-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene.[3][1][4]

2-AT has been shown to

release as well.[5][6] It is also likely to act on dopamine on account of its full substitution of d-amphetamine in rodent studies.[1][3]

Chemical derivatives

A number of

derivatives
of 2-aminotetralin exist, including:

References

  1. ^
    S2CID 19069907
    . In previous studies, 2-AT either did not stimulate spontaneous motor activity in mice (1,8), or it had 10% of the activity of amphetamine (24). Yet, in the present study, it mimicked (+)-amphetamine as a DS in rats, in agreement with the results of Glennon et al. (7). However, 2-AT was one-half as potent as (+)-amphetamine in that study but only one-eighth as potent as (+)-amphetamine in the present experiment.
  2. PMID 5116035
    .
  3. ^
    PMID 6522418
    .
  4. PMID 6123601
    .
  5. PMID 5091160
    .
  6. PMID 4257629
    .
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