2β-Propanoyl-3β-(2-naphthyl)-tropane
Source: Wikipedia, the free encyclopedia.
Chemical compound
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| Pharmacokinetic data | |
|---|---|
| Bioavailability | High[medical citation needed] |
| Elimination half-life | Slow[medical citation needed] |
| Identifiers | |
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JSmol) | |
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2β-Propanoyl-3β-(2-naphthyl)-tropane or WF-23 (Wake Forest-23, named after the university where it was first created) is a
serotonin-norepinephrine-dopamine reuptake inhibitor.[1]
As can be seen on PubMed, these acyl substituted phenyltropanes are highly potent MAT inhibitors and also have a very long half-life, spanning perhaps at least a few days;[2][3] as the half-life of the dopamine transporter in rats was found to be 2–3 days under normal conditions (with agonists, antagonists, and transporter inhibitors altering the half-life),[4] it may be that WF-23 largely or mostly binds to its transporters until they are degraded.
See also
External links
- (Satendra Singh, 2000) Page 16-17
References
- ^ U.S. patent 6,008,227
- PMID 7891330.
- PMID 9618429.
- S2CID 27253009.
| 2-Carboxymethyl Esters | |
|---|---|
| (3,4-Disubstituted Phenyl)-tropanes | |
| Arylcarboxy | |
| Carboxyalkyl | |
| Acyl | |
| β,α Stereochemistry | |
| α,β Stereochemistry | |
| Heterocycles: 3-Substituted-isoxazol-5-yl | |
| Heterocycles: 3-Substituted-1,2,4-oxadiazole | |
| N-alkyl |
|
| N-replaced (S,O,C) | |
| Irreversible |
|
| Nortropanes (N-demethylated) | |