3,4-Dichloromethylphenidate

Source: Wikipedia, the free encyclopedia.

3,4-Dichloromethylphenidate
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
Identifiers
  • Methyl (2R)-2-(3,4-dichlorophenyl)-2-[(2R)-piperidin-2-yl]acetate
JSmol)
  • N2CCCCC2C(C(=O)OC)c(cc1Cl)ccc1Cl
  • InChI=1S/C14H17Cl2NO2.ClH/c1-19-14(18)13(12-4-2-3-7-17-12)9-5-6-10(15)11(16)8-9;/h5-6,8,12-13,17H,2-4,7H2,1H3;1H/p-1/t12-,13+;/m1./s1 checkY
  • Key:DJQISAOWJXQDPU-KZCZEQIWSA-M checkY
 ☒NcheckY (what is this?)  (verify)

3,4-Dichloromethylphenidate (also known as 3,4-CTMP or 3,4-DCMP)[1] is a stimulant drug related to methylphenidate. Dichloromethylphenidate is a potent psychostimulant that acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor, meaning it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain, by binding to, and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft.

3,4-DCMP, the threo-diastereomer, is approximately seven times more potent than methylphenidate in animal studies, but has weaker reinforcing effects due to its slower onset of action.[2][3][4][5][6] However, H. M. Deutsch's discrimination ratio[clarification needed] implies it to be more reinforcing than cocaine.[4]

Legality

As of October 2015 3,4-CTMP is a controlled substance in China.[7]

3,4-CTMP was banned in the UK as a

Temporary Class Drug from April 2015 following its unapproved sale as a designer drug.[8]

Sweden's public health agency suggested to classify 3,4-CTMP as hazardous substance on 10 November 2014.[9]

See also

References

  1. ^ Wood S (10 April 2015). "Temporary Class Drug Order – legal highs' bubble to be 'burst'". Criminal Law Blog: Kingsley Napley.
  2. PMID 8632426
    .
  3. S2CID 26220081
    .
  4. ^
    PMID 11961053
    .
  5. PMID 15026075
    .
  6. PMID 17489581
    .
  7. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  8. ^ Methylphenidate-based NPS: A review of the evidence of use and harm. Advisory Council on the Misuse of Drugs, 31 March 2015
  9. ^ "Cannabinoider föreslås bli klassade som hälsofarlig vara". Retrieved 29 June 2015.
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