5-Chloro-αMT

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5-Chloro-αMT
Clinical data
ATC code
  • None
Legal status
Legal status
Identifiers
  • 1-(5-Chloro-1H-indol-3-yl)propan-2-amine
JSmol)
  • CC(Cc1c[nH]c2c1cc(cc2)Cl)N
  • InChI=1S/C11H13ClN2/c1-7(13)4-8-6-14-11-3-2-9(12)5-10(8)11/h2-3,5-7,14H,4,13H2,1H3
  • Key:QMKOQSCXSYPIPB-UHFFFAOYSA-N

5-Chloro-α-methyltryptamine (5-Chloro-αMT), also known as PAL-542, is a

serotonin receptors as well.[1]

5-Chloro-αMT was found to not reliably produce

cardiovascular effects, insomnia, hyperthermia, and anxiety) relative to SNDRAs, and thus would likely be comparatively more favorable in the treatment of cocaine dependence and other conditions.[2]

A related agent,

MDMA, has been found to produce long-lasting serotonergic neurotoxicity in rats, and the same could also prove true for 5-chloro-αMT and other monoamine-releasing tryptamines.[5]

As a 5-HT2A receptor agonist, 5-chloro-αMT very likely possesses the capacity for psychedelic effects.[1][6] Indeed, its close analog 5-fluoro-αMT produces a strong head-twitch response in rats,[7] a property which is highly correlated with psychedelic effects in humans,[6][8] and αMT is well-established as a psychedelic drug in humans.[9]

Legality

5-Chloro-AMT is illegal in Singapore.[10]

See also

References

  1. ^
    PMID 25193229
    .
  2. ^
    PMID 24796848
    .
  3. S2CID 34761939
    .
  4. S2CID 24347904
    .
  5. PMID 1722753
    .
  6. ^
    S2CID 45561708
    .
  7. PMID 9535013
    .
  8. S2CID 3148623
    .
  9. S2CID 4825078
    .
  10. ^ "Misuse of Drugs Act - Singapore Statutes Online". sso.agc.gov.sg.
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