2,5-Dimethoxy-4-fluoroamphetamine

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2,5-Dimethoxy-4-fluoroamphetamine
Clinical data
Routes of
administration		Oral, Insufflation
ATC code
  • none
Legal status
Legal status
Identifiers
  • 1-(4-Fluoro-2,5-dimethoxyphenyl)propan-2-amine
JSmol)
  • CC(Cc1cc(c(cc1OC)F)OC)N
  • InChI=1S/C11H16FNO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3 checkY
  • Key:NRANUECGGQVXOT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

2,5-Dimethoxy-4-fluoroamphetamine (DOF) is a psychedelic drug of the phenethylamine and amphetamine classes. Alexander Shulgin briefly describes DOF in his book PiHKAL:[1]

Animal studies that have compared DOF to the highly potent DOI and DOB imply that the human activity will be some four to six times less than these two heavier halide analogues.[2]

— Alexander Shulgin, (PiHKAL)

DOF showed some stimulating effects in humans, but no psychedelic activity, after three doses of 6 mg spaced by one hour.[3] Researcher Daniel Trachsel further suspected that the molar refraction of the important 4-substituent in DOF and 2C-F may be too low to activate the 5-HT2A receptor sufficiently.[4] DOF more closely mimics the effects of the 4-unsubstituted 2,5-dimethoxyamphetamine than the effects of DOC, DOB, and DOI.[5][6][7]

See also

  • 2,5-Dimethoxy-4-Substituted Amphetamines

References

  1. ISBN 978-0-9630096-0-9
    .
  2. PMID 7143352
    .
  3. ^ Nichols DE (1991). Biochemistry and Physiology of Substance Abuse, Vol. III. Boca Raton, Florida: CRC Press.
  4. PMID 22374819
    .
  5. PMID 7996545
    .
  6. PMID 1369672. Archived from the original
    on 2015-07-22. Retrieved 2015-06-29.
  7. S2CID 25077839
    .
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